Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy

Aim  To determine whether the forearm vasodilatory response to reactive hyperaemia (RH) is reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with subjects with no retinopathy. Methods  Forearm RH, an indicator of endothelial function, was measured, using str...

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Published in:Diabetic medicine 2004-08, Vol.21 (8), p.931-935
Main Authors: Gibney, J., Turner, B., Weis, U., Meeking, D. R., Cansfield, J., Watts, G. F., Shaw, K. M., Cummings, M. H.
Format: Article
Language:English
Subjects:
Age Factors
Albuminuria - blood
Biological and medical sciences
C-reactive protein
Cross-Sectional Studies
Diabetes Mellitus, Type 1 - blood
Diabetes. Impaired glucose tolerance
diabetic retinopathy
Diabetic Retinopathy - blood
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
endothelial function
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Forearm - blood supply
Humans
Hyperemia - etiology
Male
Medical sciences
Middle Aged
Ophthalmology
reactive hyperaemia
Retinopathies
Sex Factors
Type 1 diabetes mellitus
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Summary:Aim  To determine whether the forearm vasodilatory response to reactive hyperaemia (RH) is reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with subjects with no retinopathy. Methods  Forearm RH, an indicator of endothelial function, was measured, using strain‐gauge plethysmography, in 39 normoalbuminuric subjects (22 with retinopathy) with long‐standing Type 1 diabetes mellitus. Results were evaluated in relation to conventional risk factors for atherosclerosis, and C‐reactive protein (CRP), which we have recently determined to be an independent correlate of forearm RH. Results  Forearm RH was decreased in subjects with retinopathy compared with those with no retinopathy (219 ± 182 vs. 473 ± 355, P 
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2004.01203.x