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Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy
Aim To determine whether the forearm vasodilatory response to reactive hyperaemia (RH) is reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with subjects with no retinopathy. Methods Forearm RH, an indicator of endothelial function, was measured, using str...
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| Published in: | Diabetic medicine 2004-08, Vol.21 (8), p.931-935 |
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| container_end_page | 935 |
| container_issue | 8 |
| container_start_page | 931 |
| container_title | Diabetic medicine |
| container_volume | 21 |
| creator | Gibney, J. Turner, B. Weis, U. Meeking, D. R. Cansfield, J. Watts, G. F. Shaw, K. M. Cummings, M. H. |
| description | Aim To determine whether the forearm vasodilatory response to reactive hyperaemia (RH) is reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with subjects with no retinopathy.
Methods Forearm RH, an indicator of endothelial function, was measured, using strain‐gauge plethysmography, in 39 normoalbuminuric subjects (22 with retinopathy) with long‐standing Type 1 diabetes mellitus. Results were evaluated in relation to conventional risk factors for atherosclerosis, and C‐reactive protein (CRP), which we have recently determined to be an independent correlate of forearm RH.
Results Forearm RH was decreased in subjects with retinopathy compared with those with no retinopathy (219 ± 182 vs. 473 ± 355, P |
| doi_str_mv | 10.1111/j.1464-5491.2004.01203.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66733629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66733629</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4333-af6541cdda5e05c8b56a34c5825644006ece939e90621b719223dbb84aa1083d3</originalsourceid><addsrcrecordid>eNqNkMtu1DAUhi0EotOBV0DewC7Bji9JFixQKYXRUCQo6tI6cU40HnIZ7ITOvE2fhSfDYUaFJV7Ylvz95_h8hFDOUh7X623KpZaJkiVPM8ZkynjGRLp_RBYPD4_JguUySwTL-Rk5D2HLIlWK8ik54yrLWcH4gjRfsJ4s1rQZPILvaNzt6H4i3Rx26AE7B9T1tB98N0BbTZ3rJ-8sDVO1RTsGeufGDb2J8K97TmsHFY4YKPR1LDW6ftjBuDk8I08aaAM-P51L8u395c3Fh2T9-erjxdt1YqUQIoFGK8ltXYNCpmxRKQ1CWlVkSkvJmEaLcQIsmc54lfMyy0RdVYUE4KwQtViSV8e6Oz_8mDCMpnPBYttCj8MUjNa5EDpaWJLiCFo_hOCxMTvvOvAHw5mZHZutmVWaWaWZHZs_js0-Rl-cekxVh_Xf4ElqBF6eAAgW2sZDb134hyuVFFkeuTdH7s61ePjvD5h3ny7nW8wnx7wLI-4f8uC_mzhmrszt9ZXRX6_XanW7MivxG0VsqCc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66733629</pqid></control><display><type>article</type><title>Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy</title><source>Wiley</source><creator>Gibney, J. ; Turner, B. ; Weis, U. ; Meeking, D. R. ; Cansfield, J. ; Watts, G. F. ; Shaw, K. M. ; Cummings, M. H.</creator><creatorcontrib>Gibney, J. ; Turner, B. ; Weis, U. ; Meeking, D. R. ; Cansfield, J. ; Watts, G. F. ; Shaw, K. M. ; Cummings, M. H.</creatorcontrib><description>Aim To determine whether the forearm vasodilatory response to reactive hyperaemia (RH) is reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with subjects with no retinopathy.
Methods Forearm RH, an indicator of endothelial function, was measured, using strain‐gauge plethysmography, in 39 normoalbuminuric subjects (22 with retinopathy) with long‐standing Type 1 diabetes mellitus. Results were evaluated in relation to conventional risk factors for atherosclerosis, and C‐reactive protein (CRP), which we have recently determined to be an independent correlate of forearm RH.
Results Forearm RH was decreased in subjects with retinopathy compared with those with no retinopathy (219 ± 182 vs. 473 ± 355, P < 0.01). Both retinopathy and CRP proved to be independent and negative predictors, and explain 27% of the variance, in forearm RH.
Conclusion Retinopathy in subjects with Type 1 diabetes mellitus may reflect a generalized process of endothelial dysfunction, even in the absence of microalbuminuria.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2004.01203.x</identifier><identifier>PMID: 15270801</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Age Factors ; Albuminuria - blood ; Biological and medical sciences ; C-reactive protein ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1 - blood ; Diabetes. Impaired glucose tolerance ; diabetic retinopathy ; Diabetic Retinopathy - blood ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; endothelial function ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Forearm - blood supply ; Humans ; Hyperemia - etiology ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; reactive hyperaemia ; Retinopathies ; Sex Factors ; Type 1 diabetes mellitus</subject><ispartof>Diabetic medicine, 2004-08, Vol.21 (8), p.931-935</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Diabetes UK</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4333-af6541cdda5e05c8b56a34c5825644006ece939e90621b719223dbb84aa1083d3</citedby><cites>FETCH-LOGICAL-c4333-af6541cdda5e05c8b56a34c5825644006ece939e90621b719223dbb84aa1083d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15954327$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15270801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gibney, J.</creatorcontrib><creatorcontrib>Turner, B.</creatorcontrib><creatorcontrib>Weis, U.</creatorcontrib><creatorcontrib>Meeking, D. R.</creatorcontrib><creatorcontrib>Cansfield, J.</creatorcontrib><creatorcontrib>Watts, G. F.</creatorcontrib><creatorcontrib>Shaw, K. M.</creatorcontrib><creatorcontrib>Cummings, M. H.</creatorcontrib><title>Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aim To determine whether the forearm vasodilatory response to reactive hyperaemia (RH) is reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with subjects with no retinopathy.
Methods Forearm RH, an indicator of endothelial function, was measured, using strain‐gauge plethysmography, in 39 normoalbuminuric subjects (22 with retinopathy) with long‐standing Type 1 diabetes mellitus. Results were evaluated in relation to conventional risk factors for atherosclerosis, and C‐reactive protein (CRP), which we have recently determined to be an independent correlate of forearm RH.
Results Forearm RH was decreased in subjects with retinopathy compared with those with no retinopathy (219 ± 182 vs. 473 ± 355, P < 0.01). Both retinopathy and CRP proved to be independent and negative predictors, and explain 27% of the variance, in forearm RH.
Conclusion Retinopathy in subjects with Type 1 diabetes mellitus may reflect a generalized process of endothelial dysfunction, even in the absence of microalbuminuria.</description><subject>Age Factors</subject><subject>Albuminuria - blood</subject><subject>Biological and medical sciences</subject><subject>C-reactive protein</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>diabetic retinopathy</subject><subject>Diabetic Retinopathy - blood</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>endothelial function</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Forearm - blood supply</subject><subject>Humans</subject><subject>Hyperemia - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>reactive hyperaemia</subject><subject>Retinopathies</subject><subject>Sex Factors</subject><subject>Type 1 diabetes mellitus</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkMtu1DAUhi0EotOBV0DewC7Bji9JFixQKYXRUCQo6tI6cU40HnIZ7ITOvE2fhSfDYUaFJV7Ylvz95_h8hFDOUh7X623KpZaJkiVPM8ZkynjGRLp_RBYPD4_JguUySwTL-Rk5D2HLIlWK8ik54yrLWcH4gjRfsJ4s1rQZPILvaNzt6H4i3Rx26AE7B9T1tB98N0BbTZ3rJ-8sDVO1RTsGeufGDb2J8K97TmsHFY4YKPR1LDW6ftjBuDk8I08aaAM-P51L8u395c3Fh2T9-erjxdt1YqUQIoFGK8ltXYNCpmxRKQ1CWlVkSkvJmEaLcQIsmc54lfMyy0RdVYUE4KwQtViSV8e6Oz_8mDCMpnPBYttCj8MUjNa5EDpaWJLiCFo_hOCxMTvvOvAHw5mZHZutmVWaWaWZHZs_js0-Rl-cekxVh_Xf4ElqBF6eAAgW2sZDb134hyuVFFkeuTdH7s61ePjvD5h3ny7nW8wnx7wLI-4f8uC_mzhmrszt9ZXRX6_XanW7MivxG0VsqCc</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Gibney, J.</creator><creator>Turner, B.</creator><creator>Weis, U.</creator><creator>Meeking, D. R.</creator><creator>Cansfield, J.</creator><creator>Watts, G. F.</creator><creator>Shaw, K. M.</creator><creator>Cummings, M. H.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy</title><author>Gibney, J. ; Turner, B. ; Weis, U. ; Meeking, D. R. ; Cansfield, J. ; Watts, G. F. ; Shaw, K. M. ; Cummings, M. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4333-af6541cdda5e05c8b56a34c5825644006ece939e90621b719223dbb84aa1083d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age Factors</topic><topic>Albuminuria - blood</topic><topic>Biological and medical sciences</topic><topic>C-reactive protein</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>diabetic retinopathy</topic><topic>Diabetic Retinopathy - blood</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>endothelial function</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Forearm - blood supply</topic><topic>Humans</topic><topic>Hyperemia - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>reactive hyperaemia</topic><topic>Retinopathies</topic><topic>Sex Factors</topic><topic>Type 1 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibney, J.</creatorcontrib><creatorcontrib>Turner, B.</creatorcontrib><creatorcontrib>Weis, U.</creatorcontrib><creatorcontrib>Meeking, D. R.</creatorcontrib><creatorcontrib>Cansfield, J.</creatorcontrib><creatorcontrib>Watts, G. F.</creatorcontrib><creatorcontrib>Shaw, K. M.</creatorcontrib><creatorcontrib>Cummings, M. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibney, J.</au><au>Turner, B.</au><au>Weis, U.</au><au>Meeking, D. R.</au><au>Cansfield, J.</au><au>Watts, G. F.</au><au>Shaw, K. M.</au><au>Cummings, M. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2004-08</date><risdate>2004</risdate><volume>21</volume><issue>8</issue><spage>931</spage><epage>935</epage><pages>931-935</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aim To determine whether the forearm vasodilatory response to reactive hyperaemia (RH) is reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with subjects with no retinopathy.
Methods Forearm RH, an indicator of endothelial function, was measured, using strain‐gauge plethysmography, in 39 normoalbuminuric subjects (22 with retinopathy) with long‐standing Type 1 diabetes mellitus. Results were evaluated in relation to conventional risk factors for atherosclerosis, and C‐reactive protein (CRP), which we have recently determined to be an independent correlate of forearm RH.
Results Forearm RH was decreased in subjects with retinopathy compared with those with no retinopathy (219 ± 182 vs. 473 ± 355, P < 0.01). Both retinopathy and CRP proved to be independent and negative predictors, and explain 27% of the variance, in forearm RH.
Conclusion Retinopathy in subjects with Type 1 diabetes mellitus may reflect a generalized process of endothelial dysfunction, even in the absence of microalbuminuria.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15270801</pmid><doi>10.1111/j.1464-5491.2004.01203.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Age Factors Albuminuria - blood Biological and medical sciences C-reactive protein Cross-Sectional Studies Diabetes Mellitus, Type 1 - blood Diabetes. Impaired glucose tolerance diabetic retinopathy Diabetic Retinopathy - blood Endocrine pancreas. Apud cells (diseases) Endocrinopathies endothelial function Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Forearm - blood supply Humans Hyperemia - etiology Male Medical sciences Middle Aged Ophthalmology reactive hyperaemia Retinopathies Sex Factors Type 1 diabetes mellitus |
| title | Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy |
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