BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients

Abstract This study investigated the relationship between BRAF mutation, the CpG island methylator phenotype (CIMP+) and APC methylation in colorectal cancer (CRC) from young patients. The V600E BRAF mutation was found in 7% of cases and was strongly associated with the tumour features of proximal s...

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Bibliographic Details
Published in:Cancer letters 2009-01, Vol.273 (2), p.221-224
Main Authors: Ang, Pei Woon, Li, Wei Qi, Soong, Richie, Iacopetta, Barry
Format: Article
Language:English
Subjects:
Adult
APC
BRAF
CIMP
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
CpG Islands
Deoxyribonucleic acid
DNA
DNA Methylation
Female
Genes
Genotype & phenotype
Hematology, Oncology and Palliative Medicine
Histology
Humans
Male
Microsatellite Instability
Microsatellite Repeats
Middle Aged
Mutation
Patients
Phenotype
Proto-Oncogene Proteins B-raf - genetics
Studies
Tumors
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Summary:Abstract This study investigated the relationship between BRAF mutation, the CpG island methylator phenotype (CIMP+) and APC methylation in colorectal cancer (CRC) from young patients. The V600E BRAF mutation was found in 7% of cases and was strongly associated with the tumour features of proximal site, advanced stage and poor histological grade. More than half (53%) the tumours with BRAF mutation were also CIMP+ as evaluated by a standard panel of markers, compared to only 4% of tumours with wildtype BRAF ( P < 0.0001). In contrast to CIMP+, APC methylation was inversely correlated with BRAF mutation ( P = 0.02). BRAF mutation and CIMP+ are therefore likely to be involved in an alternate, albeit rare, pathway to APC inactivation during the development of CRC in younger patients.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2008.08.001