Rhabdomyosarcoma masquerading as acute leukemia

Rhabdomyosarcoma (RMS) masquerading as acute leukemia (AL) is very rare. We describe three cases with RMS without any symptoms of solid tumors. Bone marrow (BM) showed approximately 95% of blast‐like abnormal cells, lacking almost all of the surface antigens of myeloid‐ and lymphoid‐lineage. The imm...

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Bibliographic Details
Published in:Pediatric Blood & Cancer 2009-02, Vol.52 (2), p.286-287
Main Authors: Shinkoda, Yuichi, Nagatoshi, Yoshihisa, Fukano, Reiji, Nishiyama, Kenichi, Okamura, Jun
Format: Article
Language:English
Subjects:
Acute Disease
Bone Marrow Cells - pathology
Bone Marrow Examination
bone marrow involvement
Child
Diagnosis, Differential
Flow Cytometry
Humans
Immunohistochemistry
Leukemia - diagnosis
Male
rhabdomyosarcoma
Rhabdomyosarcoma - diagnosis
Rhabdomyosarcoma - pathology
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Summary:Rhabdomyosarcoma (RMS) masquerading as acute leukemia (AL) is very rare. We describe three cases with RMS without any symptoms of solid tumors. Bone marrow (BM) showed approximately 95% of blast‐like abnormal cells, lacking almost all of the surface antigens of myeloid‐ and lymphoid‐lineage. The immunohistochemistry revealed positive of the cells for actin, desmin and myoglobin. It is important to examine BM samples by immunohistochemistry, when a flow cytometric analysis reveals an unusual presentation. Pediatr Blood Cancer 2009;52:286–287. © 2008 Wiley‐Liss, Inc.
ISSN:1545-5009
1545-5017
1096-911X
DOI:10.1002/pbc.21783