Neurogenesis and depression: etiology or epiphenomenon?

The concept that decreased neurogenesis might be the cause of depression is supported by the effects of stress on neurogenesis and the demonstration that neurogenesis seems to be necessary for antidepressant action. Data from the animal models tested to date show that decreasing the rate of neurogen...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2004-08, Vol.56 (3), p.146-150
Main Authors: Henn, Fritz A, Vollmayr, Barbara
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
animal models
Animals
antidepressants
Antidepressive Agents - therapeutic use
Behavioral psychophysiology
behavioral responses
Biological and medical sciences
Brain - pathology
Cell Division - physiology
Depression
Depression - drug therapy
Depression - epidemiology
Depression - etiology
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Humans
Medical sciences
Miscellaneous
Mood disorders
neurogenesis
Neurons - pathology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Stress, Physiological - drug therapy
Stress, Physiological - physiopathology
Time Factors
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Summary:The concept that decreased neurogenesis might be the cause of depression is supported by the effects of stress on neurogenesis and the demonstration that neurogenesis seems to be necessary for antidepressant action. Data from the animal models tested to date show that decreasing the rate of neurogenesis does not lead to depressive behavior. Furthermore, evidence shows that an effective treatment for depression, transcranial magnetic stimulation, does not alter rates of neurogenesis. On the basis of these findings, it is suggested that neurogenesis might play a subtle role in depression but that it is not the primary factor in the final common pathway leading to depression.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2004.04.011