Nd:YAG surgical laser effects in canine prostate tissue: temperature and damage distribution

• Published in: Physics in medicine & biology 2009-01, Vol.54 (1), p.29-44
• Main Authors: van Nimwegen, S A, L'Eplattenier, H F, Rem, A I, van der Lugt, J J, Kirpensteijn, J
• Format: Article
• Language: English
• Subjects: Animals; Dogs; Lasers - adverse effects; Male; Models, Biological; Prostate - pathology; Prostate - radiation effects; Prostate - surgery; Prostatectomy - adverse effects; Temperature; Time Factors
• ISSN: 0031-9155; 1361-6560
• DOI: 10.1088/0031-9155/54/1/003

An in vitro model was used to predict short-term, laser-induced, thermal damage in canine prostate tissue. Canine prostate tissue samples were equipped with thermocouple probes to measure tissue temperature at 3, 6, 9 and 12 mm depths. The tissue surface was irradiated with a Nd:YAG laser in contact or non-contact mode for up to 20 s, using powers from 5 to 20 W. Prediction of thermal damage using Arrhenius theory was discussed and compared to the in vitro damage threshold, determined by histological evaluation. The threshold temperature for acute thermal tissue damage was 69 +/- 6 degrees C (means +/- SD), irrespective of exposure time. Contact mode laser application caused vaporization of tissue, leaving a crater underneath the fiber tip. The mean extent of tissue damage underneath the vaporization crater floor was 0.9 +/- 0.6 mm after 5, 10 or 20 s of contact mode laser irradiation at 10 W, whereas 20 W non-contact exposure up to 20 s causes up to 4.7 +/- 0.2 mm coagulation necrosis. It was concluded that short-term acute thermal tissue damage can be comprehensively described by a single threshold temperature.