Steroids linked with amide bond—Extended cholesterol

New type of linear cholesterol-like molecules based on cholesterol extended by attachment of etienic acid derivatives was designed and oligosteroids with two to four units were synthesized. Amide bond was used for inter steroid connections and 1-hydroxybenzotriazole active ester method was adapted f...

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Bibliographic Details
Published in:Steroids 2009, Vol.74 (1), p.88-94
Main Authors: Černý, Ivan, Buděšínský, Miloš, Pouzar, Vladimír, Drašar, Pavel
Format: Article
Language:English
Subjects:
Amides
Amides - chemistry
Androstenes - chemistry
Biological and medical sciences
Cholesterol - chemical synthesis
Cholesterol - chemistry
Fundamental and applied biological sciences. Psychology
Molecular Structure
Oligomers
Synthesis
Vertebrates: endocrinology
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Summary:New type of linear cholesterol-like molecules based on cholesterol extended by attachment of etienic acid derivatives was designed and oligosteroids with two to four units were synthesized. Amide bond was used for inter steroid connections and 1-hydroxybenzotriazole active ester method was adapted for their formations. Use of disteroids as larger building blocks was applied.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2008.09.010