Anthropomorphic measurements and event-free survival in patients with favorable histology Wilms tumor: A report from the Children's Oncology Group

• Published in: Pediatric blood & cancer 2009-02, Vol.52 (2), p.254-258
• Main Authors: Fernandez, Conrad V., Anderson, James, Breslow, Norman E., Dome, Jeffrey S., Grundy, P.E., Perlman, Elizabeth J., Green, Daniel M.
• Format: Article
• Language: English
• Subjects: Age Factors; Body Height; Body Mass Index; Body Weight; Child; Child, Preschool; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; Disease-Free Survival; Humans; Infant; Loss of Heterozygosity; Nephrectomy; Prognosis; Prospective Studies; Wilms; Wilms Tumor - genetics; Wilms Tumor - mortality; Wilms Tumor - pathology
• ISSN: 1545-5009; 1545-5017
• DOI: 10.1002/pbc.21809

Purpose We retrospectively examined the effect of body weight and body mass index (BMI) on event‐free survival (EFS) of children with Wilms tumor treated on National Wilms Tumor Study‐5 (NWTS‐5). Patients and methods Eligible study participants: stages I–IV favorable histology Wilms tumor with immediate nephrectomy; height and weight recorded at diagnosis, and loss of heterozygosity for chromosomes 1p and 16q assessed. Results A total of 1,532 patients were included in the analysis. The median follow‐up was 4.9 years. 493 patients were less than 2 years of age and 1039 were 2 years of age or older. In both age groups there were more patients than expected with a weight or body mass index (BMI) less than the 10‰ or greater than the 90‰. There was no relationship of weight‐for‐age or BMI‐for‐age and EFS in univariate analyses (P = 0.28, log‐rank test for both comparisons). A Cox proportional hazards model, stratified by risk/treatment groups, showed that, among patients less than 2 years of age, low or high weight‐for‐age was not predictive of EFS (P = 0.16). Similarly, a Cox proportional hazards model, stratified by risk/treatment groups, showed that among patients greater than 2 years of age, low or high body mass index for age was not predictive of EFS (P = 0.58). Conclusions There was no evidence that anthropomorphic data obtained at diagnosis for patients with favorable histology stages I–IV Wilms tumor was predictive for EFS in the setting of current treatment regimens. There were more patients with lower or higher weight/BMI than expected. Pediatr Blood Cancer 2009;52:254–258. © 2008 Wiley‐Liss, Inc.