Mesenchymal Stem Cells and Neurodegenerative Disease

The prospect of cell therapy for incurable neurodegenerative disease excites scientists, the public, and patients alike. Clinical and scientific enthusiasm must, however, always be tempered by methodological rigor and by the overwhelming imperative of protecting vulnerable sufferers. We tentatively...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2009-01, Vol.85 (1), p.19-20
Main Authors: Whone, AL, Scolding, NJ
Format: Article
Language:English
Subjects:
Cell Differentiation
Feasibility Studies
Humans
Mesenchymal Stem Cell Transplantation - adverse effects
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - immunology
Neurodegenerative Diseases - therapy
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Summary:The prospect of cell therapy for incurable neurodegenerative disease excites scientists, the public, and patients alike. Clinical and scientific enthusiasm must, however, always be tempered by methodological rigor and by the overwhelming imperative of protecting vulnerable sufferers. We tentatively suggest that, in the case of autologous mesenchymal stem cells (MSCs), the balance between our current understanding of their biology and an informed assessment of their probable safety allows a case to be made for cautious pilot clinical studies. Clinical Pharmacology & Therapeutics (2009); 85, 1, 19–20 doi:10.1038/clpt.2008.205
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2008.205