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Transmission of Yersinia pestis from an infectious biofilm in the flea vector
Transmission of plague by fleas depends on infection of the proventricular valve in the insect's foregut by a dense aggregate of Yersinia pestis. Proventricular infection requires the Y. pestis hemin storage (hms) genes; here, we show that the hms genes are also required to produce an extracell...
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| Published in: | The Journal of infectious diseases 2004-08, Vol.190 (4), p.782-792 |
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| Main Authors: | , , , , , , , , |
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| Language: | English |
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| container_end_page | 792 |
| container_issue | 4 |
| container_start_page | 782 |
| container_title | The Journal of infectious diseases |
| container_volume | 190 |
| creator | Jarrett, Clayton O. Deak, Eszter Isherwood, Karen E. Oyston, Petra C. Fischer, Elizabeth R. Whitney, Adeline R. Kobayashi, Scott D. DeLeo, Frank R. Hinnebusch, B. Joseph |
| description | Transmission of plague by fleas depends on infection of the proventricular valve in the insect's foregut by a dense aggregate of Yersinia pestis. Proventricular infection requires the Y. pestis hemin storage (hms) genes; here, we show that the hms genes are also required to produce an extracellular matrix and a biofilm in vitro, supporting the hypothesis that a transmissible infection in the flea depends on the development of a biofilm on the hydrophobic, acellular surface of spines that line the interior of the proventriculus. The development of biofilm and proventricular infection did not depend on the 3 Y. pestis quorum-sensing systems. The extracellular matrix enveloping the Y. pestis biofilm in the flea appeared to incorporate components from the flea's blood meal, and bacteria released from the biofilm were more resistant to human polymorphonuclear leukocytes than were in vitro-grown Y. pestis. Enabling arthropod-borne transmission represents a novel function of a bacterial biofilm. |
| doi_str_mv | 10.1086/422695 |
| format | article |
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The extracellular matrix enveloping the Y. pestis biofilm in the flea appeared to incorporate components from the flea's blood meal, and bacteria released from the biofilm were more resistant to human polymorphonuclear leukocytes than were in vitro-grown Y. pestis. Enabling arthropod-borne transmission represents a novel function of a bacterial biofilm.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/422695</identifier><identifier>PMID: 15272407</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Bacteria ; Bacterial Proteins - genetics ; Bacteriology ; Biofilms ; Biofilms - growth & development ; Biological and medical sciences ; Disease transmission ; Disease Transmission, Infectious ; Evolution, Molecular ; Extracellular matrix ; Female ; Fleas ; Fundamental and applied biological sciences. 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Joseph</creatorcontrib><title>Transmission of Yersinia pestis from an infectious biofilm in the flea vector</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><addtitle>J Infect Dis</addtitle><description>Transmission of plague by fleas depends on infection of the proventricular valve in the insect's foregut by a dense aggregate of Yersinia pestis. Proventricular infection requires the Y. pestis hemin storage (hms) genes; here, we show that the hms genes are also required to produce an extracellular matrix and a biofilm in vitro, supporting the hypothesis that a transmissible infection in the flea depends on the development of a biofilm on the hydrophobic, acellular surface of spines that line the interior of the proventriculus. The development of biofilm and proventricular infection did not depend on the 3 Y. pestis quorum-sensing systems. The extracellular matrix enveloping the Y. pestis biofilm in the flea appeared to incorporate components from the flea's blood meal, and bacteria released from the biofilm were more resistant to human polymorphonuclear leukocytes than were in vitro-grown Y. pestis. Enabling arthropod-borne transmission represents a novel function of a bacterial biofilm.</description><subject>Animals</subject><subject>Bacteria</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacteriology</subject><subject>Biofilms</subject><subject>Biofilms - growth & development</subject><subject>Biological and medical sciences</subject><subject>Disease transmission</subject><subject>Disease Transmission, Infectious</subject><subject>Evolution, Molecular</subject><subject>Extracellular matrix</subject><subject>Female</subject><subject>Fleas</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Immunity, Cellular</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Insect Vectors - microbiology</subject><subject>Major Articles and Brief Reports</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Midgut</subject><subject>Miscellaneous</subject><subject>Neutrophils - microbiology</subject><subject>Phenotypes</subject><subject>Plague - transmission</subject><subject>Proventriculus</subject><subject>Siphonaptera - microbiology</subject><subject>Siphonaptera - ultrastructure</subject><subject>Yersinia pestis</subject><subject>Yersinia pestis - genetics</subject><subject>Yersinia pestis - physiology</subject><subject>Yersinia pestis - ultrastructure</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkluLFDEQhYMo7jjqP1CioG-tlXvnUQZ1hV1clhUvLyGTTjBjd2dMukX_vVl72AFBfEkg50vVqZwg9JDACwKtfMkplVrcQisimGqkJOw2WgFQ2pBW6xN0r5QdAHAm1V10QgRVlINaofOrbMcyxFJiGnEK-LPPJY7R4r0vUyw45DRgO-I4Bu-mmOaCtzGF2A_1CE9fPQ69t_hHFVO-j-4E2xf_4LCv0Yc3r682p83Z-7fvNq_OGse5nura0c62EDoNgUqqAhfUE9E5T8BXBCThjlMutra1ToiWUs467TTlpPNbtkbPl7r7nL7P1aipEzjf93b01aGRUnEm6p3_gaQFTkGRCj79C9ylOY91CEMp0wR4C8dqLqdSsg9mn-Ng8y9DwFzHYJYYKvj4UG3eDr47Yod3r8CzA2CLs32oIbhYjpwkROg_tp4sXJr3_272aGF2pUZwQzEApa4_who1ix7L5H_e6DZ_M1IxJczppy_mfEMvLi_JhfnIfgMuOa-c</recordid><startdate>20040815</startdate><enddate>20040815</enddate><creator>Jarrett, Clayton O.</creator><creator>Deak, Eszter</creator><creator>Isherwood, Karen E.</creator><creator>Oyston, Petra C.</creator><creator>Fischer, Elizabeth R.</creator><creator>Whitney, Adeline R.</creator><creator>Kobayashi, Scott D.</creator><creator>DeLeo, Frank R.</creator><creator>Hinnebusch, B. 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Psychology</topic><topic>Gastrointestinal Tract - microbiology</topic><topic>Immunity, Cellular</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Insect Vectors - microbiology</topic><topic>Major Articles and Brief Reports</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Midgut</topic><topic>Miscellaneous</topic><topic>Neutrophils - microbiology</topic><topic>Phenotypes</topic><topic>Plague - transmission</topic><topic>Proventriculus</topic><topic>Siphonaptera - microbiology</topic><topic>Siphonaptera - ultrastructure</topic><topic>Yersinia pestis</topic><topic>Yersinia pestis - genetics</topic><topic>Yersinia pestis - physiology</topic><topic>Yersinia pestis - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jarrett, Clayton O.</creatorcontrib><creatorcontrib>Deak, Eszter</creatorcontrib><creatorcontrib>Isherwood, Karen E.</creatorcontrib><creatorcontrib>Oyston, Petra C.</creatorcontrib><creatorcontrib>Fischer, Elizabeth R.</creatorcontrib><creatorcontrib>Whitney, Adeline R.</creatorcontrib><creatorcontrib>Kobayashi, Scott D.</creatorcontrib><creatorcontrib>DeLeo, Frank R.</creatorcontrib><creatorcontrib>Hinnebusch, B. 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Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission of Yersinia pestis from an infectious biofilm in the flea vector</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>J Infect Dis</stitle><addtitle>J Infect Dis</addtitle><date>2004-08-15</date><risdate>2004</risdate><volume>190</volume><issue>4</issue><spage>782</spage><epage>792</epage><pages>782-792</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Transmission of plague by fleas depends on infection of the proventricular valve in the insect's foregut by a dense aggregate of Yersinia pestis. Proventricular infection requires the Y. pestis hemin storage (hms) genes; here, we show that the hms genes are also required to produce an extracellular matrix and a biofilm in vitro, supporting the hypothesis that a transmissible infection in the flea depends on the development of a biofilm on the hydrophobic, acellular surface of spines that line the interior of the proventriculus. The development of biofilm and proventricular infection did not depend on the 3 Y. pestis quorum-sensing systems. The extracellular matrix enveloping the Y. pestis biofilm in the flea appeared to incorporate components from the flea's blood meal, and bacteria released from the biofilm were more resistant to human polymorphonuclear leukocytes than were in vitro-grown Y. pestis. Enabling arthropod-borne transmission represents a novel function of a bacterial biofilm.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15272407</pmid><doi>10.1086/422695</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2004-08, Vol.190 (4), p.782-792 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | Animals Bacteria Bacterial Proteins - genetics Bacteriology Biofilms Biofilms - growth & development Biological and medical sciences Disease transmission Disease Transmission, Infectious Evolution, Molecular Extracellular matrix Female Fleas Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - microbiology Immunity, Cellular Infections Infectious diseases Insect Vectors - microbiology Major Articles and Brief Reports Male Medical sciences Microbiology Midgut Miscellaneous Neutrophils - microbiology Phenotypes Plague - transmission Proventriculus Siphonaptera - microbiology Siphonaptera - ultrastructure Yersinia pestis Yersinia pestis - genetics Yersinia pestis - physiology Yersinia pestis - ultrastructure |
| title | Transmission of Yersinia pestis from an infectious biofilm in the flea vector |
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