Hypertensive Status and Lipoprotein Oxidation in an Elderly Population at High Cardiovascular Risk

Background In elderly individuals, hypertension is a main risk factor for cardiovascular disease and oxidative damage is increased. Our aim was to assess the relationship between the degree of in vivo low-density lipoprotein (oxLDL) oxidation and the hypertensive status in a elderly population at hi...

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Bibliographic Details
Published in:American journal of hypertension 2009-01, Vol.22 (1), p.68-73
Main Authors: Guxens, Mònica, Fitó, Montserrat, Martínez-González, Miguel-Angel, Salas-Salvadó, Jordi, Estruch, Ramón, Vinyoles, Ernest, Fiol, Miguel, Corella, Dolores, Arós, Fernando, Gómez-Gracia, Enrique, Ruiz-Gutiérrez, Valentina, Lapetra, José, Ros, Emili, Vila, Joan, Covas, María-Isabel
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Coronary Disease - epidemiology
Coronary Disease - etiology
Coronary Disease - prevention & control
Cross-Sectional Studies
Diet, Mediterranean
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Hypertension - blood
Hypertension - complications
Hypertension - physiopathology
Incidence
Lipid Peroxidation
Lipoproteins - blood
Male
Medical sciences
Middle Aged
Oxidative Stress
Prognosis
Retrospective Studies
Risk Factors
Severity of Illness Index
United States - epidemiology
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Summary:Background In elderly individuals, hypertension is a main risk factor for cardiovascular disease and oxidative damage is increased. Our aim was to assess the relationship between the degree of in vivo low-density lipoprotein (oxLDL) oxidation and the hypertensive status in a elderly population at high cardiovascular risk. Methods Cross-sectional study with baseline data from the PREDIMED (PREvención con DIeta MEDiterránea) trial, an intervention study directed at testing the efficacy of the Mediterranean diet on the primary prevention of cardiovascular disease. Participants were 1,130 subjects at high cardiovascular risk aged 55–80. At baseline, in vivo circulating oxLDL was measured, and stages of hypertension determined according to the USA Joint National Committee guidelines. Results A positive relationship between in vivo oxLDL and systolic and diastolic blood pressure (DBP) was observed after adjusting for confounding factors (P < 0.05). OxLDL concentrations increased in a linear manner from low to high hypertensive stages (P < 0.05). Conclusions Elderly individuals at high cardiovascular risk showed higher levels of circulating oxLDL when their hypertensive status increased. This fact identifies the hypertensive elderly population as a target for antioxidant preventive measures. American Journal of Hypertension (2009). doi:10.1038/ajh.2008.313
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1038/ajh.2008.313