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Pulmonary 15NO uptake in interstitial lung disease
Because lung nitric oxide (NO) diffusing capacity ( D L) represents alveolar–capillary gas diffusion, we queried as to whether disturbances of pulmonary gas exchange in interstitial lung disease (ILD) are appropriately reflected by using NO. In this pilot study, we applied the 15N-labeled stable iso...
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| Published in: | Nitric oxide 2004-06, Vol.10 (4), p.229-232 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c1999-a01b9544835aeb2452149d0c5206abecd47fa6e0392f7c48107c99c8130efb3e3 |
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| cites | cdi_FETCH-LOGICAL-c1999-a01b9544835aeb2452149d0c5206abecd47fa6e0392f7c48107c99c8130efb3e3 |
| container_end_page | 232 |
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| container_title | Nitric oxide |
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| creator | Heller, H. Korbmacher, N. Gäbler, R. Brandt, S. Breitbach, T. Juergens, U. Grohé, C. Schuster, K.-D. |
| description | Because lung nitric oxide (NO) diffusing capacity (
D
L) represents alveolar–capillary gas diffusion, we queried as to whether disturbances of pulmonary gas exchange in interstitial lung disease (ILD) are appropriately reflected by using NO. In this pilot study, we applied the
15N-labeled stable isotope
15NO (relative abundance 0.37% of total NO) in order to ignore the endogenous NO production. In 10 ILD-outpatients, we measured
D
L
15NO by performing the single-breath method. Lung function parameters as well as arterial oxygen partial pressure (PaO
2) were also tested. Values of
D
L
15NO ranged within 50–151
ml
15NO/(mmHg
min). Ratios of
D
L
15NO/reference were between 43 and 108% of predicted data as taken from our previous work on healthy volunteers [Eur. J. Physiol. 446 (2003) 256]. We found a significant reduction of
D
L
15NO/reference in five patients. Additionally, values of PaO
2 were significantly correlated to ratios of
D
L
15NO/reference (adjusted
R
2
±
SEE=0.407
±
8.051). In conclusion,
15NO represents an appropriate indicator gas for reflecting an ILD-induced impairment of alveolar–capillary gas exchange. |
| doi_str_mv | 10.1016/j.niox.2004.06.001 |
| format | article |
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D
L) represents alveolar–capillary gas diffusion, we queried as to whether disturbances of pulmonary gas exchange in interstitial lung disease (ILD) are appropriately reflected by using NO. In this pilot study, we applied the
15N-labeled stable isotope
15NO (relative abundance 0.37% of total NO) in order to ignore the endogenous NO production. In 10 ILD-outpatients, we measured
D
L
15NO by performing the single-breath method. Lung function parameters as well as arterial oxygen partial pressure (PaO
2) were also tested. Values of
D
L
15NO ranged within 50–151
ml
15NO/(mmHg
min). Ratios of
D
L
15NO/reference were between 43 and 108% of predicted data as taken from our previous work on healthy volunteers [Eur. J. Physiol. 446 (2003) 256]. We found a significant reduction of
D
L
15NO/reference in five patients. Additionally, values of PaO
2 were significantly correlated to ratios of
D
L
15NO/reference (adjusted
R
2
±
SEE=0.407
±
8.051). In conclusion,
15NO represents an appropriate indicator gas for reflecting an ILD-induced impairment of alveolar–capillary gas exchange.</description><identifier>ISSN: 1089-8603</identifier><identifier>EISSN: 1089-8611</identifier><identifier>DOI: 10.1016/j.niox.2004.06.001</identifier><identifier>PMID: 15275869</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>15N-labeled nitric oxide ; Adult ; Female ; Humans ; Lung - metabolism ; Lung Diseases, Interstitial - metabolism ; Male ; Middle Aged ; Nitric Oxide - metabolism ; Nitrogen Isotopes - metabolism ; Single-breath diffusing capacity</subject><ispartof>Nitric oxide, 2004-06, Vol.10 (4), p.229-232</ispartof><rights>2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1999-a01b9544835aeb2452149d0c5206abecd47fa6e0392f7c48107c99c8130efb3e3</citedby><cites>FETCH-LOGICAL-c1999-a01b9544835aeb2452149d0c5206abecd47fa6e0392f7c48107c99c8130efb3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15275869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heller, H.</creatorcontrib><creatorcontrib>Korbmacher, N.</creatorcontrib><creatorcontrib>Gäbler, R.</creatorcontrib><creatorcontrib>Brandt, S.</creatorcontrib><creatorcontrib>Breitbach, T.</creatorcontrib><creatorcontrib>Juergens, U.</creatorcontrib><creatorcontrib>Grohé, C.</creatorcontrib><creatorcontrib>Schuster, K.-D.</creatorcontrib><title>Pulmonary 15NO uptake in interstitial lung disease</title><title>Nitric oxide</title><addtitle>Nitric Oxide</addtitle><description>Because lung nitric oxide (NO) diffusing capacity (
D
L) represents alveolar–capillary gas diffusion, we queried as to whether disturbances of pulmonary gas exchange in interstitial lung disease (ILD) are appropriately reflected by using NO. In this pilot study, we applied the
15N-labeled stable isotope
15NO (relative abundance 0.37% of total NO) in order to ignore the endogenous NO production. In 10 ILD-outpatients, we measured
D
L
15NO by performing the single-breath method. Lung function parameters as well as arterial oxygen partial pressure (PaO
2) were also tested. Values of
D
L
15NO ranged within 50–151
ml
15NO/(mmHg
min). Ratios of
D
L
15NO/reference were between 43 and 108% of predicted data as taken from our previous work on healthy volunteers [Eur. J. Physiol. 446 (2003) 256]. We found a significant reduction of
D
L
15NO/reference in five patients. Additionally, values of PaO
2 were significantly correlated to ratios of
D
L
15NO/reference (adjusted
R
2
±
SEE=0.407
±
8.051). In conclusion,
15NO represents an appropriate indicator gas for reflecting an ILD-induced impairment of alveolar–capillary gas exchange.</description><subject>15N-labeled nitric oxide</subject><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>Lung - metabolism</subject><subject>Lung Diseases, Interstitial - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitrogen Isotopes - metabolism</subject><subject>Single-breath diffusing capacity</subject><issn>1089-8603</issn><issn>1089-8611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMo7rr6BzxIT95aJ0mTNuBFFr9gcT3oOaTpVLJ22zVpRf-9WXbRmzAwc3jeF-Yh5JxCRoHKq1XWuf4rYwB5BjIDoAdkSqFUaSkpPfy9gU_ISQgriCAv5TGZUMEKUUo1Jex5bNd9Z_x3QsXTMhk3g3nHxHVxBvRhcIMzbdKO3VtSu4Am4Ck5akwb8Gy_Z-T17vZl_pAulveP85tFaqlSKjVAKyXyvOTCYMVywWiuarCCgTQV2jovGiMRuGJNYfOSQmGVsiXlgE3Fkc_I5a534_uPEcOg1y5YbFvTYT8GLWUhgAoeQbYDre9D8NjojXfr-JKmoLem9EpvTemtKQ1SR1MxdLFvH6s11n-RvZoIXO8AjD9-OvQ6WIedxdp5tIOue_df_w-C1HiX</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Heller, H.</creator><creator>Korbmacher, N.</creator><creator>Gäbler, R.</creator><creator>Brandt, S.</creator><creator>Breitbach, T.</creator><creator>Juergens, U.</creator><creator>Grohé, C.</creator><creator>Schuster, K.-D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200406</creationdate><title>Pulmonary 15NO uptake in interstitial lung disease</title><author>Heller, H. ; Korbmacher, N. ; Gäbler, R. ; Brandt, S. ; Breitbach, T. ; Juergens, U. ; Grohé, C. ; Schuster, K.-D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1999-a01b9544835aeb2452149d0c5206abecd47fa6e0392f7c48107c99c8130efb3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>15N-labeled nitric oxide</topic><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>Lung - metabolism</topic><topic>Lung Diseases, Interstitial - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitrogen Isotopes - metabolism</topic><topic>Single-breath diffusing capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heller, H.</creatorcontrib><creatorcontrib>Korbmacher, N.</creatorcontrib><creatorcontrib>Gäbler, R.</creatorcontrib><creatorcontrib>Brandt, S.</creatorcontrib><creatorcontrib>Breitbach, T.</creatorcontrib><creatorcontrib>Juergens, U.</creatorcontrib><creatorcontrib>Grohé, C.</creatorcontrib><creatorcontrib>Schuster, K.-D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nitric oxide</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heller, H.</au><au>Korbmacher, N.</au><au>Gäbler, R.</au><au>Brandt, S.</au><au>Breitbach, T.</au><au>Juergens, U.</au><au>Grohé, C.</au><au>Schuster, K.-D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary 15NO uptake in interstitial lung disease</atitle><jtitle>Nitric oxide</jtitle><addtitle>Nitric Oxide</addtitle><date>2004-06</date><risdate>2004</risdate><volume>10</volume><issue>4</issue><spage>229</spage><epage>232</epage><pages>229-232</pages><issn>1089-8603</issn><eissn>1089-8611</eissn><abstract>Because lung nitric oxide (NO) diffusing capacity (
D
L) represents alveolar–capillary gas diffusion, we queried as to whether disturbances of pulmonary gas exchange in interstitial lung disease (ILD) are appropriately reflected by using NO. In this pilot study, we applied the
15N-labeled stable isotope
15NO (relative abundance 0.37% of total NO) in order to ignore the endogenous NO production. In 10 ILD-outpatients, we measured
D
L
15NO by performing the single-breath method. Lung function parameters as well as arterial oxygen partial pressure (PaO
2) were also tested. Values of
D
L
15NO ranged within 50–151
ml
15NO/(mmHg
min). Ratios of
D
L
15NO/reference were between 43 and 108% of predicted data as taken from our previous work on healthy volunteers [Eur. J. Physiol. 446 (2003) 256]. We found a significant reduction of
D
L
15NO/reference in five patients. Additionally, values of PaO
2 were significantly correlated to ratios of
D
L
15NO/reference (adjusted
R
2
±
SEE=0.407
±
8.051). In conclusion,
15NO represents an appropriate indicator gas for reflecting an ILD-induced impairment of alveolar–capillary gas exchange.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15275869</pmid><doi>10.1016/j.niox.2004.06.001</doi><tpages>4</tpages></addata></record> |
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| issn | 1089-8603 1089-8611 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66750153 |
| source | Elsevier |
| subjects | 15N-labeled nitric oxide Adult Female Humans Lung - metabolism Lung Diseases, Interstitial - metabolism Male Middle Aged Nitric Oxide - metabolism Nitrogen Isotopes - metabolism Single-breath diffusing capacity |
| title | Pulmonary 15NO uptake in interstitial lung disease |
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