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Biogenic amine receptors in parasitic nematodes: what can be learned from Caenorhabditis elegans?

The biogenic amines, serotonin, octopamine, tyramine and dopamine regulate many essential processes in parasitic nematodes, such as pharyngeal pumping, muscle contraction, and egg-laying, as well as more complex behaviors, such as mechanosensation and foraging, making biogenic amine receptors excell...

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Published in:Molecular & Biochemical Parasitology 2004-09, Vol.137 (1), p.1-11
Main Authors: Komuniecki, Richard W., Hobson, Robert J., Rex, Elizabeth B., Hapiak, Vera M., Komuniecki, Patricia R.
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description The biogenic amines, serotonin, octopamine, tyramine and dopamine regulate many essential processes in parasitic nematodes, such as pharyngeal pumping, muscle contraction, and egg-laying, as well as more complex behaviors, such as mechanosensation and foraging, making biogenic amine receptors excellent targets for drug discovery. This review is designed to summarize our knowledge of nematode biogenic amine signaling and preliminarily identify some of the key receptors involved in the regulation of biogenic amine-dependent behaviors through an analysis of the free-living nematode, Caenorhabditis elegans.
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subjects 5-HT
animal models
animal parasitic nematodes
Animals
Biogenic amine receptors
biogenic amines
C. elegans
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Caenorhabditis elegans - physiology
chemoreceptors
Dopamine - metabolism
feeding behavior
free-living nematodes
integument
literature reviews
Locomotion
Muscle Contraction
mutants
Nematoda - physiology
Nematode
Octopamine
Octopamine - metabolism
oviposition
pharyngeal pumping
pharynx
Pharynx - physiology
physiological regulation
receptor null mutants
Receptors, Biogenic Amine - genetics
Receptors, Biogenic Amine - physiology
Reproduction
Serotonin - metabolism
signal transduction
Tyramine
Tyramine - metabolism
title Biogenic amine receptors in parasitic nematodes: what can be learned from Caenorhabditis elegans?
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