Maternal separation suppresses TGFα mRNA expression in the prefrontal cortex of male and female neonatal C57BL/6 mice

Male C57BL/6 mice that undergo maternal separation (MS) early in life demonstrate higher levels of anxiety upon reaching adulthood compared to normally reared offspring. This study reports that neonatal males and females that undergo MS have reduced mRNA levels of transforming growth factor-α (TGFα)...

Full description

Saved in:
Bibliographic Details
Published in:Brain research. Developmental brain research 2004-08, Vol.152 (1), p.73-77
Main Authors: Romeo, Russell D, Fossella, John A, Bateup, Helen S, Sisti, Helene M, Brake, Wayne G, McEwen, Bruce S
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Female
Hippocampus
Male
Maternal Deprivation
Maternal separation
Mice
Mice, Inbred C57BL
Neonatal
Prefrontal cortex
Prefrontal Cortex - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
TGFα
Transforming Growth Factor alpha - biosynthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Male C57BL/6 mice that undergo maternal separation (MS) early in life demonstrate higher levels of anxiety upon reaching adulthood compared to normally reared offspring. This study reports that neonatal males and females that undergo MS have reduced mRNA levels of transforming growth factor-α (TGFα) in the prefrontal cortex, an area of the brain implicated in emotionality, compared to normally reared animals. TGFα expression was unaffected by MS in the hippocampus. These data indicate that MS leads to a brain region-specific suppression of TGFα expression early in development.
ISSN:0165-3806
DOI:10.1016/j.devbrainres.2004.05.007