Amides from Streptomyces hygroscopicus and their antimicrobial activity [corrected]

Three amides, N-salicyloyl-2-aminopropan-1,3-diol (1) and 1-acetyl-N-salicyloyl-2-aminopropan-3-ol (2) including a natural product, N-salicyloyl-2-aminopropan-1-ol (3) were isolated from an ethyl acetate extract of the culture filtrate of Streptomyces hygroscopicus [corrected] The structures of thes...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2004-07, Vol.65 (14), p.2147-2151
Main Authors: Hossain, M Shamim, Hossain, M Aslam, Rahman, M Mukhlesur, Mondol, M A Mojid, Bhuiyan, M S A, Gray, Alexander I, Flores, Maria E, Rashid, Mohammad A
Format: Article
Language:English
Subjects:
Amides - chemistry
Amides - isolation & purification
Anti-Bacterial Agents - chemistry
Antifungal Agents - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Optical Rotation
Streptomyces - chemistry
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Summary:Three amides, N-salicyloyl-2-aminopropan-1,3-diol (1) and 1-acetyl-N-salicyloyl-2-aminopropan-3-ol (2) including a natural product, N-salicyloyl-2-aminopropan-1-ol (3) were isolated from an ethyl acetate extract of the culture filtrate of Streptomyces hygroscopicus [corrected] The structures of these compounds were unambiguously established by interpretation of their spectral data including, a series of 1D and 2D-NMR and MS analyses. Compounds 1-3 showed significant antibacterial activity against a wide range of Gram positive and Gram negative bacteria.
ISSN:0031-9422