The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination

The vertebrate immune system generates double-strand DNA (dsDNA) breaks to generate the antigen receptor repertoire of lymphocytes. After those double-strand breaks have been created, the DNA joinings required to complete the process are carried out by the nonhomologous DNA end joining pathway, or N...

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Bibliographic Details
Published in:DNA Repair 2004-08, Vol.3 (8), p.817-826
Main Authors: Lieber, Michael R, Ma, Yunmei, Pannicke, Ulrich, Schwarz, Klaus
Format: Article
Language:English
Subjects:
Animals
Artemis
DNA Damage
DNA ligase IV
DNA Repair
DNA-dependent protein kinase
DNA-PKcs
Double-strand break repair
Genetic recombination
Humans
Immunoglobulin gene recombination
Immunoglobulins - genetics
Ku70
Ku86
Lymphocytes - physiology
Models, Biological
Models, Genetic
Oxygen - metabolism
RAG-1
RAG-2
Recombination activating genes
Recombination, Genetic
Severe combined immune deficiency
V(D)J recombination
VDJ Recombinases - physiology
XRCC4
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Summary:The vertebrate immune system generates double-strand DNA (dsDNA) breaks to generate the antigen receptor repertoire of lymphocytes. After those double-strand breaks have been created, the DNA joinings required to complete the process are carried out by the nonhomologous DNA end joining pathway, or NHEJ. The NHEJ pathway is present not only in lymphocytes, but in all eukaryotic cells ranging from yeast to humans. The NHEJ pathway is needed to repair these physiologic breaks, as well as challenging pathologic breaks that arise from ionizing radiation and oxidative damage to DNA.
ISSN:1568-7864
1568-7856
DOI:10.1016/j.dnarep.2004.03.015