Murine B7-H3 Is a Negative Regulator of T Cells

T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. B7-H3 is a novel B7-like molecule with a putative receptor on activated T cells. Human B7-H3 was first described as a positive costimulator, most potently inducing IFN-gamma production a...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2004-08, Vol.173 (4), p.2500-2506
Main Authors: Prasad, Durbaka V. R, Nguyen, Thang, Li, Zhaoxia, Yang, Yang, Duong, Julie, Wang, Ying, Dong, Chen
Format: Article
Language:English
Subjects:
Animals
Antibodies, Blocking
Antigen-Presenting Cells - immunology
B-Lymphocytes - immunology
B7 Antigens
B7-1 Antigen - immunology
Cells, Cultured
Cytokines - immunology
Dendritic Cells - immunology
Encephalomyelitis, Autoimmune, Experimental - immunology
Female
Flow Cytometry
Lymphocyte Activation - immunology
Macrophages - immunology
Mice
Rats
T-Lymphocytes - immunology
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Summary:T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. B7-H3 is a novel B7-like molecule with a putative receptor on activated T cells. Human B7-H3 was first described as a positive costimulator, most potently inducing IFN-gamma production and cellular immunity. In this study we examined the expression and function of mouse B7-H3. B7-H3 is mostly expressed on professional APCs; its expression on dendritic cells appears to be up-regulated by LPS. In contrast to human B7-H3, we found that mouse B7-H3 protein inhibited T cell activation and effector cytokine production. An antagonistic mAb to B7-H3 enhanced T cell proliferation in vitro and led to exacerbated experimental autoimmune encephalomyelitis in vivo. Therefore, mouse B7-H3 serves as a negative regulator of T cell activation and function.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.173.4.2500