Vascular CO Counterbalances the Sensitizing Influence of 20-HETE on Agonist-Induced Vasoconstriction

We examined the influence of interactions between CO and 20-hydroxyeicosatetraenoic acid (20-HETE) on vascular reactivity to phenylephrine and vasopressin. Renal interlobar arteries incubated in Krebs buffer released CO at a rate that is decreased (from 125.0±15.2 to 46.3±8.8 pmol/mg protein per hou...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-08, Vol.44 (2), p.210-216
Main Authors: Kaide, Jun-Ichi, Zhang, Fan, Wei, Yuan, Wang, WenHui, Gopal, Venkat Raj, Falck, John R, Laniado-Schwartzman, Michal, Nasjletti, Alberto
Format: Article
Language:English
Subjects:
Adrenergic Agonists - pharmacology
Animals
Arterial hypertension. Arterial hypotension
Arteries - drug effects
Arteries - metabolism
Biological and medical sciences
Blood and lymphatic vessels
Blood vessels and receptors
Carbon Monoxide - metabolism
Cardiology. Vascular system
Dose-Response Relationship, Drug
Experimental diseases
Fundamental and applied biological sciences. Psychology
Hydroxyeicosatetraenoic Acids - pharmacology
In Vitro Techniques
Male
Medical sciences
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
Patch-Clamp Techniques
Phenylephrine - pharmacology
Potassium Channels - metabolism
Rats
Rats, Sprague-Dawley
Renal Artery
Renal Circulation
Vasoconstriction
Vasopressins - pharmacology
Vertebrates: cardiovascular system
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Summary:We examined the influence of interactions between CO and 20-hydroxyeicosatetraenoic acid (20-HETE) on vascular reactivity to phenylephrine and vasopressin. Renal interlobar arteries incubated in Krebs buffer released CO at a rate that is decreased (from 125.0±15.2 to 46.3±8.8 pmol/mg protein per hour, P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000135658.57547.bb