Reduced expression of liver–intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma

Liver–intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the co...

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Bibliographic Details
Published in:Cancer letters 2004-08, Vol.212 (2), p.253-259
Main Authors: Takamura, Masaaki, Ichida, Takafumi, Matsuda, Yasunobu, Kobayashi, Masaaki, Yamagiwa, Satoshi, Genda, Takuya, Shioji, Kazuhiko, Hashimoto, Satoru, Nomoto, Minoru, Hatakeyama, Katsuyoshi, Ajioka, Yoichi, Sakamoto, Michiie, Hirohashi, Setsuo, Aoyagi, Yutaka
Format: Article
Language:English
Subjects:
Aged
Amino acids
Antibodies, Monoclonal
Cadherins
Cancer therapies
Carcinoma - metabolism
Carcinoma - pathology
Carrier Proteins - biosynthesis
Cell adhesion & migration
Cell culture
Cell Differentiation
Cell Line, Tumor
Colon
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Disease Progression
Female
Humans
Immunoblotting
Immunohistochemistry
Liver
Liver - metabolism
Liver–intestine cadherin
Lymph node metastasis
Lymphatic Metastasis
Male
Medical prognosis
Membrane Transport Proteins
Middle Aged
monoclonal antibody
Phenotype
Proteins
Rodents
Tumors
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Summary:Liver–intestine cadherin (LI-cadherin) is a recently identified member of the cadherin superfamily. We examined LI-cadherin expression in four human colorectal carcinoma cell lines and 45 human primary colorectal carcinomas using a monoclonal antibody against LI-cadherin. We also investigated the correlation between LI-cadherin expression and clinicopathologic parameters. Among the cell lines, LI-cadherin expression was detected in a differentiated phenotype, but not in dedifferentiated phenotypes. Among the 45 tumor samples, LI-cadherin expression was preserved in 28 (62%) and reduced in 17 (38%). Reduced LI-cadherin expression was significantly associated with a high tumor grade ( P=0.015), lymphatic invasion ( P=0.033), lymph node metastasis ( P=0.015), and an advanced pTNM stage ( P=0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2004.03.016