Temporal trends in coronary heart disease mortality and sudden cardiac death from 1950 to 1999: the Framingham Heart Study

Throughout the past 50 years, heart disease has been the leading cause of death in the United States. Although declines in coronary heart disease (CHD) mortality have been noted, there is still uncertainty about the magnitude of the decline and whether the trend is similar for sudden cardiac death (...

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Published in:Circulation (New York, N.Y.) N.Y.), 2004-08, Vol.110 (5), p.522-527
Main Authors: Fox, Caroline S, Evans, Jane C, Larson, Martin G, Kannel, William B, Levy, Daniel
Format: Article
Language:English
Subjects:
Adult
Cohort Studies
Coronary Disease - mortality
Death, Sudden, Cardiac - epidemiology
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Mortality - trends
Prospective Studies
Risk
United States - epidemiology
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container_title Circulation (New York, N.Y.)
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creator Fox, Caroline S
Evans, Jane C
Larson, Martin G
Kannel, William B
Levy, Daniel
description Throughout the past 50 years, heart disease has been the leading cause of death in the United States. Although declines in coronary heart disease (CHD) mortality have been noted, there is still uncertainty about the magnitude of the decline and whether the trend is similar for sudden cardiac death (SCD). We examined temporal trends in SCD and nonsudden CHD death in the Framingham Heart Study original and offspring cohorts from 1950 to 1999. SCD was defined as a death attributed to CHD with preceding symptoms that lasted less than 1 hour; all deaths were adjudicated by a physician panel. Log-linear Poisson regression was used to estimate CHD mortality and SCD risk ratios (RRs); RRs were adjusted for age and gender. There were 811 CHD deaths: 453 nonsudden and 358 SCDs. Ninety-one (20%) of nonsudden CHD deaths and 173 (48%) of SCDs were in subjects free of antecedent CHD. From 1950-1969 to 1990-1999, overall CHD death rates decreased by 59% (95% CI 47% to 68%, P(trend)
doi_str_mv 10.1161/01.CIR.0000136993.34344.41
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source Free E-Journal (出版社公開部分のみ）
subjects Adult
Cohort Studies
Coronary Disease - mortality
Death, Sudden, Cardiac - epidemiology
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Mortality - trends
Prospective Studies
Risk
United States - epidemiology
title Temporal trends in coronary heart disease mortality and sudden cardiac death from 1950 to 1999: the Framingham Heart Study
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