Isoflurane increases, but sevoflurane decreases blood concentrations of melatonin in women

The blood concentrations of melatonin are elevated by stress-induced sympathetic nerve excitation and are affected by some anesthetics. Isoflurane has an effect to increase sympathetic nerve activity when compared with sevoflurane. This study was performed to investigate the effects of these two ane...

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Bibliographic Details
Published in:Journal of anesthesia 2004-08, Vol.18 (3), p.228-231
Main Authors: Arai, Young-Chang P, Ueda, Wasa, Okatani, Yuji, Fukaya, Takao, Manabe, Masanobu
Format: Article
Language:English
Subjects:
Adult
Anesthetics, Inhalation - pharmacology
Female
Heart Rate - drug effects
Humans
Isoflurane - pharmacology
Melatonin - blood
Methyl Ethers - pharmacology
Middle Aged
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Summary:The blood concentrations of melatonin are elevated by stress-induced sympathetic nerve excitation and are affected by some anesthetics. Isoflurane has an effect to increase sympathetic nerve activity when compared with sevoflurane. This study was performed to investigate the effects of these two anesthetics on the blood concentrations of melatonin. Female patients were anesthetized with either isoflurane or sevoflurane. We obtained blood samples before and 5 min after 5% isoflurane (ISO group) or 7% sevoflurane (SEV group) anesthesia. The blood melatonin concentrations during anesthesia in the ISO group increased significantly, from 65 +/- 60 to 170 +/- 90 pg x ml(-l); mean +/- SD ( P < 0.05), whereas those in the SEV group decreased, from 60 +/- 50 to 30 +/- 30 pg x ml(-l) ( P < 0.05). In conclusion, isoflurane increases, but sevoflurane decreases blood melatonin concentrations.
ISSN:0913-8668
1438-8359
DOI:10.1007/s00540-004-0249-1