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Ameloblastin gene ( AMBN) mutations associated with epithelial odontogenic tumors
Ameloblastin ( AMBN, MIM ∗601259) gene expresses an important protein (AMBN), present in the organic matrix of enamel. The AMBN protein has an important role in the differentiation of ameloblast cells and epithelium-mesenchyme signaling during odontogenesis which prompted us to investigate this gene...
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| Published in: | Oral oncology 2004-09, Vol.40 (8), p.841-846 |
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| Language: | English |
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| container_end_page | 846 |
| container_issue | 8 |
| container_start_page | 841 |
| container_title | Oral oncology |
| container_volume | 40 |
| creator | Perdigão, P.F Gomez, R.S Pimenta, F.J.G.S De Marco, L |
| description | Ameloblastin (
AMBN, MIM ∗601259) gene expresses an important protein (AMBN), present in the organic matrix of enamel. The AMBN protein has an important role in the differentiation of ameloblast cells and epithelium-mesenchyme signaling during odontogenesis which prompted us to investigate this gene in aggressive epithelial odontogenic tumors, such as ameloblastomas, and in some non-aggressive ones, such as the adenomatoid odontogenic tumor and the squamous odontogenic tumor. Six cases of epithelial odontogenic tumors were studied and normal cells of the patient's mucosa were used as negative controls. The results demonstrated novel mutations in all tumors, while mucosal cells showed the wild type DNA sequence. Our data demonstrates that
AMBN gene has an important role in the tumorigenesis of subtypes of epithelial odontogenic tumors and that this phenotypic heterogeneity could be caused by genetic heterogeneity. |
| doi_str_mv | 10.1016/j.oraloncology.2004.03.004 |
| format | article |
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AMBN, MIM ∗601259) gene expresses an important protein (AMBN), present in the organic matrix of enamel. The AMBN protein has an important role in the differentiation of ameloblast cells and epithelium-mesenchyme signaling during odontogenesis which prompted us to investigate this gene in aggressive epithelial odontogenic tumors, such as ameloblastomas, and in some non-aggressive ones, such as the adenomatoid odontogenic tumor and the squamous odontogenic tumor. Six cases of epithelial odontogenic tumors were studied and normal cells of the patient's mucosa were used as negative controls. The results demonstrated novel mutations in all tumors, while mucosal cells showed the wild type DNA sequence. Our data demonstrates that
AMBN gene has an important role in the tumorigenesis of subtypes of epithelial odontogenic tumors and that this phenotypic heterogeneity could be caused by genetic heterogeneity.</description><identifier>ISSN: 1368-8375</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/j.oraloncology.2004.03.004</identifier><identifier>PMID: 15288841</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>AMBN ; Ameloblastin ; Ameloblastoma ; Ameloblastoma - genetics ; Ameloblastoma - pathology ; Base Sequence ; Biological and medical sciences ; Dental Enamel Proteins - genetics ; Epithelial Cells - pathology ; Epithelial odontogenic tumors ; Exons - genetics ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Humans ; Medical sciences ; Molecular Sequence Data ; Mouth Mucosa - pathology ; Mouth Neoplasms - genetics ; Mouth Neoplasms - pathology ; Mutation ; Odontogenic Tumors - genetics ; Odontogenic Tumors - pathology ; Otorhinolaryngology. Stomatology ; Tumors</subject><ispartof>Oral oncology, 2004-09, Vol.40 (8), p.841-846</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-546f2c291ef3ae60618d8e8d7739e0e357f2ad645e389cf8268fb961b0dba04b3</citedby><cites>FETCH-LOGICAL-c470t-546f2c291ef3ae60618d8e8d7739e0e357f2ad645e389cf8268fb961b0dba04b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16000934$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15288841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perdigão, P.F</creatorcontrib><creatorcontrib>Gomez, R.S</creatorcontrib><creatorcontrib>Pimenta, F.J.G.S</creatorcontrib><creatorcontrib>De Marco, L</creatorcontrib><title>Ameloblastin gene ( AMBN) mutations associated with epithelial odontogenic tumors</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>Ameloblastin (
AMBN, MIM ∗601259) gene expresses an important protein (AMBN), present in the organic matrix of enamel. The AMBN protein has an important role in the differentiation of ameloblast cells and epithelium-mesenchyme signaling during odontogenesis which prompted us to investigate this gene in aggressive epithelial odontogenic tumors, such as ameloblastomas, and in some non-aggressive ones, such as the adenomatoid odontogenic tumor and the squamous odontogenic tumor. Six cases of epithelial odontogenic tumors were studied and normal cells of the patient's mucosa were used as negative controls. The results demonstrated novel mutations in all tumors, while mucosal cells showed the wild type DNA sequence. Our data demonstrates that
AMBN gene has an important role in the tumorigenesis of subtypes of epithelial odontogenic tumors and that this phenotypic heterogeneity could be caused by genetic heterogeneity.</description><subject>AMBN</subject><subject>Ameloblastin</subject><subject>Ameloblastoma</subject><subject>Ameloblastoma - genetics</subject><subject>Ameloblastoma - pathology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Dental Enamel Proteins - genetics</subject><subject>Epithelial Cells - pathology</subject><subject>Epithelial odontogenic tumors</subject><subject>Exons - genetics</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Mouth Mucosa - pathology</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mutation</subject><subject>Odontogenic Tumors - genetics</subject><subject>Odontogenic Tumors - pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Tumors</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkUuLFDEUhYMoztj6FyQIyrioMqlUHuWuHZ8wKoKuQyq5NaZJVdokpcy_N003jCsVQk4W3zk33IPQE0paSqh4sWtjMiEuNoZ4fdN2hPQtYW2VO-icKjk0hA_sbn0zoRrFJD9DD3LeEUI45eQ-OqO8U0r19Bx92c4Q4hhMLn7B17AAvsDbj68-PcfzWkzxccnY5BytNwUc_uXLdwz7ekPwJuDo4lJi9XmLyzrHlB-ie5MJGR6ddIO-vX3z9fJ9c_X53YfL7VVje0lKw3sxdbYbKEzMgCCCKqdAOSnZAAQYl1NnnOg5MDXYSXVCTeMg6EjcaEg_sg16dszdp_hjhVz07LOFEMwCcc1aCClEx1UFL_4K1o1xxWVP6D8zqRQDZ_Vs0MsjaFPMOcGk98nPJt1oSvShJL3Tf5akDyVpwnSVan58mrKOM7hb66mVCjw9ASZbE6ZkFuvzLSdqkwM7BL0-clD3_NND0tl6WCw4n8AW7aL_n__8BhHxtsQ</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Perdigão, P.F</creator><creator>Gomez, R.S</creator><creator>Pimenta, F.J.G.S</creator><creator>De Marco, L</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Ameloblastin gene ( AMBN) mutations associated with epithelial odontogenic tumors</title><author>Perdigão, P.F ; Gomez, R.S ; Pimenta, F.J.G.S ; De Marco, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-546f2c291ef3ae60618d8e8d7739e0e357f2ad645e389cf8268fb961b0dba04b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>AMBN</topic><topic>Ameloblastin</topic><topic>Ameloblastoma</topic><topic>Ameloblastoma - genetics</topic><topic>Ameloblastoma - pathology</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Dental Enamel Proteins - genetics</topic><topic>Epithelial Cells - pathology</topic><topic>Epithelial odontogenic tumors</topic><topic>Exons - genetics</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Mouth Mucosa - pathology</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mutation</topic><topic>Odontogenic Tumors - genetics</topic><topic>Odontogenic Tumors - pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perdigão, P.F</creatorcontrib><creatorcontrib>Gomez, R.S</creatorcontrib><creatorcontrib>Pimenta, F.J.G.S</creatorcontrib><creatorcontrib>De Marco, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perdigão, P.F</au><au>Gomez, R.S</au><au>Pimenta, F.J.G.S</au><au>De Marco, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ameloblastin gene ( AMBN) mutations associated with epithelial odontogenic tumors</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>40</volume><issue>8</issue><spage>841</spage><epage>846</epage><pages>841-846</pages><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>Ameloblastin (
AMBN, MIM ∗601259) gene expresses an important protein (AMBN), present in the organic matrix of enamel. The AMBN protein has an important role in the differentiation of ameloblast cells and epithelium-mesenchyme signaling during odontogenesis which prompted us to investigate this gene in aggressive epithelial odontogenic tumors, such as ameloblastomas, and in some non-aggressive ones, such as the adenomatoid odontogenic tumor and the squamous odontogenic tumor. Six cases of epithelial odontogenic tumors were studied and normal cells of the patient's mucosa were used as negative controls. The results demonstrated novel mutations in all tumors, while mucosal cells showed the wild type DNA sequence. Our data demonstrates that
AMBN gene has an important role in the tumorigenesis of subtypes of epithelial odontogenic tumors and that this phenotypic heterogeneity could be caused by genetic heterogeneity.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15288841</pmid><doi>10.1016/j.oraloncology.2004.03.004</doi><tpages>6</tpages></addata></record> |
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| ispartof | Oral oncology, 2004-09, Vol.40 (8), p.841-846 |
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| source | ScienceDirect Freedom Collection |
| subjects | AMBN Ameloblastin Ameloblastoma Ameloblastoma - genetics Ameloblastoma - pathology Base Sequence Biological and medical sciences Dental Enamel Proteins - genetics Epithelial Cells - pathology Epithelial odontogenic tumors Exons - genetics Facial bones, jaws, teeth, parodontium: diseases, semeiology Humans Medical sciences Molecular Sequence Data Mouth Mucosa - pathology Mouth Neoplasms - genetics Mouth Neoplasms - pathology Mutation Odontogenic Tumors - genetics Odontogenic Tumors - pathology Otorhinolaryngology. Stomatology Tumors |
| title | Ameloblastin gene ( AMBN) mutations associated with epithelial odontogenic tumors |
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