Acute leukemia of donor origin arising after stem cell transplantation for acute promyelocytic leukemia

We report a patient with PML/RARα-positive acute promyelocytic leukemia (APL) who developed PML/RARα-negative acute myeloid leukemia 37 months after allogeneic bone marrow (BMT) transplant for molecular relapse. Features of myelodysplasia were noted 11 months earlier, chimerism testing by analysis o...

Full description

Saved in:
Bibliographic Details
Published in:Leukemia research 2004-10, Vol.28 (10), p.1107-1111
Main Authors: Daly, Andrew S, Kamel-Reid, Suzanne, Lipton, Jeffrey H, Messner, Hans A, Kiss, Thomas L, Chun, Kathy, Busque, Lambert, Chang, Hong
Format: Article
Language:English
Subjects:
Acute Disease
Acute promyelocytic leukemia
Adult
Allogeneic bone marrow transplantation
Donor cell leukemia
Female
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Leukemia, Myeloid - diagnosis
Leukemia, Myeloid - etiology
Leukemia, Myeloid - therapy
Leukemia, Promyelocytic, Acute - pathology
Leukemia, Promyelocytic, Acute - therapy
Neoplasms, Second Primary - diagnosis
Neoplasms, Second Primary - etiology
Neoplasms, Second Primary - therapy
Recurrence
Remission Induction
Tissue Donors
Transplantation, Homologous
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a patient with PML/RARα-positive acute promyelocytic leukemia (APL) who developed PML/RARα-negative acute myeloid leukemia 37 months after allogeneic bone marrow (BMT) transplant for molecular relapse. Features of myelodysplasia were noted 11 months earlier, chimerism testing by analysis of short tandem repeats was consistent with development of myelodysplasia and acute leukemia within cells of donor origin. To our knowledge, this is the first report of donor cell leukemia following BMT for APL. We hypothesize that replicative stress may lead to the development of some cases of donor cell acute leukemia.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2004.02.003