Tone probe event-related potential differences during a face recognition task in prepubertal children and Turner Syndrome girls

• Published in: Psychoneuroendocrinology 2004-11, Vol.29 (10), p.1260-1271
• Main Authors: Everhart, D.Erik, Shucard, Janet L, Quatrin, Teresa, Shucard, David W
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation; Adolescent; Behavioral psychophysiology; Biological and medical sciences; Brain organisation; Cerebral Cortex - physiology; Cerebral Cortex - physiopathology; Child; Electrophysiology; Estrogen; Evoked Potentials, Auditory - physiology; Face; Female; Female genital diseases; Functional Laterality - physiology; Fundamental and applied biological sciences. Psychology; Gynecology. Andrology. Obstetrics; Hormones; Hormones and behavior; Human; Humans; Learning. Memory; Male; Medical sciences; Memory; Non tumoral diseases; Perceptual Masking - physiology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Puberty - physiology; Recognition (Psychology) - physiology; Reference Values; Sex Characteristics; Sex Factors; Sex-differences; Turner Syndrome - physiopathology
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/j.psyneuen.2004.03.004

Hormones have been shown to play a role in both cerebral development and neurocognitive function. Turner Syndrome (TS) provides the opportunity to study the effect of the lack of estrogen on neurocognitive development. In this study, event-related potential (ERP) differences were examined among 12 TS girls, 20 prepubertal control girls, and 20 prepubertal control boys during a face recognition memory task. Stage of puberty was determined by Tanner Scale rating and hormonal assay. ERPs to pairs of auditory probe stimuli were recorded from eight scalp sites while participants performed a faced recognition memory (FRM) task. For the N2 component of the ERP (which has previously been associated with evaluation of stimulus information, categorization difficulty, and attention), control boys displayed greater right versus left hemisphere amplitude, control girls displayed greater left versus right hemisphere amplitude, and there was no amplitude asymmetry for TS girls. Further, control girls had greater left hemisphere N2 amplitude than control boys and TS girls, and greater right hemisphere N2 amplitude than TS girls. The results suggest more right hemisphere activation during face recognition in boys, while the opposite pattern was present in control girls. In contrast, TS girls displayed no asymmetry, indicative of more uniform involvement of the left and right hemispheres during face recognition. These findings are consistent with differences in cortical organization related to face recognition memory processing among prepubertal control boys, girls, and TS girls. They also support the notion that sex differences in cognitive function are present prior to pubertal onset, and that lack of endogenous sex hormones (e.g., estrogen) during prenatal/perinatal development (i.e., for TS girls) may influence brain organization and, in turn, neurocognitive processes that relate to face recognition.