Results of surgical treatment of sporadic medullary thyroid carcinoma following routine measurement of serum calcitonin

Aim. The aim of this study was to evaluate the results of the surgical management of medullary thyroid carcinoma (MTC), following the introduction of systematic calcitonin measurement in patients referred for thyroid diseases. Method. We included all the patients with elevated calcitonin and MTC fro...

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Bibliographic Details
Published in:European journal of surgical oncology 2004-09, Vol.30 (7), p.790-795
Main Authors: Mirallié, E, Iacobone, M, Sebag, F, Henry, J.F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
Calcitonin - blood
Carcinoma, Medullary - blood
Carcinoma, Medullary - diagnosis
Carcinoma, Medullary - pathology
Carcinoma, Medullary - surgery
Female
Humans
Male
Medical Records
Medullary thyroid carcinoma
Middle Aged
Neoplasm Staging
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity
Serum calcitonin
Thyroid Neoplasms - blood
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Treatment Outcome
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Summary:Aim. The aim of this study was to evaluate the results of the surgical management of medullary thyroid carcinoma (MTC), following the introduction of systematic calcitonin measurement in patients referred for thyroid diseases. Method. We included all the patients with elevated calcitonin and MTC from January 1993 to March 2001. Results. Among 8497 patients, MTC was diagnosed in 52 with a mean age of 56.1 years. Thirty-two fine needle biopsies led to diagnose MTC in 19 cases. The median basal pre-operative calcitonin level was 245 pg/ml. Elevated calcitonin serum was the only indicator of MTC in 31 patients. Fifty-one patients underwent total thyroidectomies, with lymphadenectomy in 45. Thirteen patients had lymph node involvement. Post-operatively, 40 (77%) had normal basal and pentagastrin (Pg) stimulated calcitonin serum levels, and remained normal at a mean follow-up of 5.16 years (1.8–8). Conclusion. Routine pre-operative measurement of calcitonin should be performed because it is often the only indicator of MTC at an early stage. This could lead to an improved MTC cure rate.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2004.05.016