In Situ Formation of a Heterobimetallic Chiral [(Salen)TiIV]/[(Salen)VV] Catalyst for the Asymmetric Addition of TMSCN to Benzaldehyde

A mixed complex which results from two salen‐derived VV and TiIV complexes (1 and 2), catalyzes the trimethylsilylcyanation of aldehydes. The reaction kinetics are largely determined by the titanium‐derived portion, whereas the configuration of the mandelonitrile trimethylsilyl ether products is det...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2004-08, Vol.43 (31), p.4085-4089
Main Authors: Belokon, Yuri N., North, Michael, Maleev, Victor I., Voskoboev, Nikolay V., Moskalenko, Margarita A., Peregudov, Alexander S., Dmitriev, Andrey V., Ikonnikov, Nikolai S., Kagan, Henri B.
Format: Article
Language:English
Subjects:
asymmetric catalysis
cooperative effects
heterobimetallic complexes
titanium
vanadium
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Summary:A mixed complex which results from two salen‐derived VV and TiIV complexes (1 and 2), catalyzes the trimethylsilylcyanation of aldehydes. The reaction kinetics are largely determined by the titanium‐derived portion, whereas the configuration of the mandelonitrile trimethylsilyl ether products is determined by the slower vanadium part of the catalyst. salen=N,N'‐bis(salicylaldehydo)ethylenediamine.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200454031