Prognostic significance of Ki-67 expression for patients with laryngeal squamous cell carcinoma primarily treated by total laryngectomy

The aim of this study was to determine the prognostic value of Ki-67 immunostaining in laryngeal squamous cell carcinomas. Ki-67 labeling was quantified in 63 laryngeal squamous cell carcinomas by counting at least 1,000 tumor cells in the most immunoreactive area in each sample, and the Ki-67 label...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2004-08, Vol.261 (7), p.376-380
Main Authors: ACIKALIN, Mustafa Fuat, ÖNER, Ülkü, TEL, Nilüfer, PASAOGGLU, Özgül, CAKLI, Hamdi, COLAK, Ertugrul
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - surgery
Cell Division
Female
Humans
Immunohistochemistry
Ki-67 Antigen - analysis
Laryngeal Neoplasms - chemistry
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
Laryngectomy
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Neoplasm Recurrence, Local
Otorhinolaryngology. Stomatology
Prognosis
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:The aim of this study was to determine the prognostic value of Ki-67 immunostaining in laryngeal squamous cell carcinomas. Ki-67 labeling was quantified in 63 laryngeal squamous cell carcinomas by counting at least 1,000 tumor cells in the most immunoreactive area in each sample, and the Ki-67 labeling index was calculated as a percentage. The antigen expression was compared with clinical factors, histopathological grading and prognosis. The Ki-67 mean proliferation index for all patients was 25.44% ( range, 2-75%). A significant correlation was found between Ki-67 mean proliferation index and patient age ( P
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-003-0699-3