Bronchointerstitial Pneumonia in Guinea Pigs Following Inoculation with H5N1 High Pathogenicity Avian Influenza Virus

The H5N1 high-pathogenicity avian influenza (HPAI) viruses have caused widespread disease of poultry in Asia, Africa and the Middle East, and sporadic human infections. The guinea pig model has been used to study human H3N2 and H1N1 influenza viruses, but knowledge is lacking on H5N1 HPAI virus infe...

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Bibliographic Details
Published in:Veterinary pathology 2009, Vol.46 (1), p.138-141
Main Authors: Kwon, Y.K, Lipatov, A.S, Swayne, D.E
Format: Article
Language:English
Subjects:
animal disease models
Animals
avian influenza
Bronchopneumonia - etiology
Bronchopneumonia - pathology
Disease Models, Animal
disease resistance
experimental infection
Guinea Pigs
histopathology
infection
Influenza A virus
Influenza A Virus, H5N1 Subtype - pathogenicity
intragastric administration
intranasal administration
laboratory animals
Lung - pathology
Lung - virology
lungs
Orthomyxoviridae Infections - complications
pathogenesis
pathogenicity
viral pneumonia
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Summary:The H5N1 high-pathogenicity avian influenza (HPAI) viruses have caused widespread disease of poultry in Asia, Africa and the Middle East, and sporadic human infections. The guinea pig model has been used to study human H3N2 and H1N1 influenza viruses, but knowledge is lacking on H5N1 HPAI virus infections. Guinea pigs were inoculated intranasally or intragastrically with A/Vietnam/1203/04 (VN/04) or A/Muscovy duck/Vietnam/209/05 (MDk/VN/05) viruses. Mild listlessness was seen at 2 and 3 days postinoculation (DPI) in guinea pigs inoculated intranasally with VN/04 virus. At 5 DPI, the guinea pigs had bronchointerstitial pneumonia and virus was identified in bronchiolar epithelium and alveolar macrophages. Virus was isolated from the lungs but was lacking from other organs. Minimal lung lesions were seen in intranasal MDk/VN/06 group and virus was not detected, but serologic evidence of infection was observed. Intragastric exposure failed to produce infection or lesions with either virus. The localized respiratory disease in guinea pigs with H5N1 viruses was very similar to that of H3N2 and H1N1 influenza in humans and was less severe than reported for H5N1 human cases.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.46-1-138