Systemic host inflammatory and coagulation response in the Dengue virus primo-infection

• Published in: Cytokine (Philadelphia, Pa.) Pa.), 2004-09, Vol.27 (6), p.173-179
• Main Authors: Avila-Aguero, Marı́a L, Avila-Aguero, Claudio R, Um, Suzane L, Soriano-Fallas, Alejandra, Cañas-Coto, Alejandro, Yan, S.Betty
• Format: Article
• Language: English
• Subjects: Activated protein C; Adolescent; Adult; Aged; Animals; Biomarkers; Blood Coagulation - physiology; Coagulopathy; Cytokines; Cytokines - blood; Dengue; Dengue - blood; Dengue - immunology; Dengue - physiopathology; Dengue virus; Dengue Virus - immunology; Female; Humans; Inflammation; Inflammatory response; Middle Aged; Prospective Studies
• ISSN: 1043-4666; 1096-0023
• DOI: 10.1016/j.cyto.2004.05.007

Dengue virus infection has been rising in tropical countries. Clinical manifestations range from fever and general malaise to hemorrhagic manifestations and death. The role of endothelial damage and cytokines has not been well established for dengue infection. Determine the profile of the pro-inflammatory cytokines and several markers of coagulopathy of dengue infection. Patients admitted between September 2000 and April 2001, who met the WHO dengue diagnosis criteria, were enrolled. Blood samples were collected at 0, 6, 12, 24, 48, 72 h and 5 and 7 days after hospitalization. Profile of pro-inflammatory cytokines, markers of coagulopathy, protein C, protein S, d-dimer, prothrombin time, activated partial thromboplastin time, fibrinogen and activated protein C levels were determined. Thirty-three patients were enrolled. Median (range) age was 31 (13–70) years; 51.5% (17/33) were female. Ten of 33 (30%) presented with hemorrhagic manifestations. Patients were classified: Grade 1: 23/33 (70%), Grade II: 10/33 (30%). At study entry IL-6 was the most elevated, followed by IL-8 and TNFα. IL-10 was not elevated. No significant differences ( p