Lipid peroxidation and inguinal hernia repair. Tension-free vs. Andrews technique

Aim of the study: To evaluate the early effect of inguinal hernia repair by the tension-free method compared to the conventional Andrew's technique on lipid peroxidation. Patients-methods: Thirty-four patients subjected to elective hernia repair were enrolled in the study divided in two groups....

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Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2004-10, Vol.71 (4), p.221-225
Main Authors: Papaziogas, Basilios, Koutelidakis, Ioannis M., Giamarellos-Bourboulis, Evangelos J., Lazaridis, Charalambos, Koussoulas, Vassilios, Galanis, Ioannis, Giamarellou, Helen, Atmatzidis, Konstantinos
Format: Article
Language:English
Subjects:
Biological and medical sciences
Female
Fibrinogen - analysis
Fundamental and applied biological sciences. Psychology
Hernia, Inguinal - blood
Hernia, Inguinal - therapy
Humans
Inflammatory response
Leukocyte Count
Lipid Peroxidation
Male
Malondialdehyde
Malondialdehyde - blood
Middle Aged
Polypropylenes
Tension-free technique
Vertebrates: endocrinology
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Summary:Aim of the study: To evaluate the early effect of inguinal hernia repair by the tension-free method compared to the conventional Andrew's technique on lipid peroxidation. Patients-methods: Thirty-four patients subjected to elective hernia repair were enrolled in the study divided in two groups. Group A ( n=18) underwent hernia repair by the tension-free method using a polypropylene mesh. Group B ( n=16) underwent hernia repair by the Andrew's technique (i.e. a modification of the Bassini's technique). Venous blood samples were drawn preoperatively and at 12, 24 and 48 h postoperatively. Malondialdehyde (MDA) was estimated by the thiobarbiturate assay. Results: Neutrophil counts were significantly higher in patients of group B compared to group A at 12 and 48 h postoperatively. Concentrations of fibrinogen were similar between the two groups. MDA was significantly higher in patients of group B hours compared to group A at 12, 24 and 48 h postoperatively. Positive correlation was found between neutrophil counts and MDA at 12 h ( r: +0.43, P: 0.015) and 48 h ( r: +0.496, P: 0.005) but not at 24 h. No correlation was found between serum fibrinogen and MDA. Conclusion: Hernia repair by the Andrews's technique elicits a sustained triggering of lipid peroxidation, compared to the tension-free method.
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2004.03.016