Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP)

THOC7 and Fms-interacting protein (FMIP) are members of the THO complex that associate with the mRNA export apparatus. FMIP is a nucleocytoplasmic shuttling protein with a nuclear localization signal (NLS), whereas THOC7 does not contain a typical NLS motif. We show here that THOC7 (50–137, amino ac...

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Published in:FEBS letters 2009-01, Vol.583 (1), p.13-18
Main Authors: El Bounkari, Omar, Guria, Anuja, Klebba-Faerber, Sabine, Claußen, Maike, Pieler, Tomas, Griffiths, John R., Whetton, Anthony D., Koch, Alexandra, Tamura, Teruko
Format: Article
Language:English
Subjects:
Amino Acid Motifs - genetics
Animals
Cell Nucleus - metabolism
FMIP/THOC5/fSAP79
Humans
Mice
mRNA processing complex
Mutation
Nuclear Localization Signals - genetics
Nuclear Localization Signals - metabolism
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Nucleocytoplasmic shuttling protein
Protein Interaction Mapping
RNA Precursors - metabolism
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
THOC7/fSAP24
Xenopus
Xenopus Proteins - genetics
Xenopus Proteins - metabolism
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cited_by cdi_FETCH-LOGICAL-c5064-3432c4986ff866f0e82e2c0558c66e25ff41fd507b80cc3fac1ba946d2856ee03
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container_volume 583
creator El Bounkari, Omar
Guria, Anuja
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Claußen, Maike
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Griffiths, John R.
Whetton, Anthony D.
Koch, Alexandra
Tamura, Teruko
description THOC7 and Fms-interacting protein (FMIP) are members of the THO complex that associate with the mRNA export apparatus. FMIP is a nucleocytoplasmic shuttling protein with a nuclear localization signal (NLS), whereas THOC7 does not contain a typical NLS motif. We show here that THOC7 (50–137, amino acid numbers) binds to the N-terminal portion (1–199) of FMIP directly. FMIP is detected mainly in the nucleus. In the absence of exogenous FMIP, THOC7 resides mainly in the cytoplasm, while in the presence of FMIP, THOC7 is transported into the nucleus with FMIP. Furthermore, THOC7 lacking the FMIP binding site does not co-localize with FMIP, indicating that THOC7/FMIP interaction is required for nuclear localization of THOC7. MINT-6799962, MINT-6799973, MINT-6800005: THOC7 (uniprotkb:Q6I9Y2) physically interacts (MI:0218) with THOC5 (uniprotkb:Q13769) by pull down (MI:0096) MINT-6800108: FMIP (uniprotkb:Q13769) and THOC7 (uniprotkb: Q6I9Y2) co-localize (MI:0403) by fluorescence microscopy (MI:0416) MINT-6800052: FMIP (uniprotkb:Q13769) physically interacts (MI:0218) with THOC1 (uniprotkb: Q96FV9) by anti tag coimmunoprecipitation (MI:0007) MINT-6800022: THOC7 (uniprotkb:Q6I9Y2) physically interacts (MI:0218) with FMIP (uniprotkb:Q6DFL5) by pull down (MI:0096) MINT-6799989: THOC7 (uniprotkb:Q6I9Y2) binds (MI:0407) to FMIP (uniprotkb:Q13769) by pull down (MI:0096) MINT-6800071, MINT-6800089: FMIP (uniprotkb:Q13769) physically interacts (MI:0218) with THOC7 (uniprotkb:Q6I9Y2) and THOC1 (uniprotkb:Q96FV9) by anti tag coimmunoprecipitation (MI:0007)
doi_str_mv 10.1016/j.febslet.2008.11.024
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FMIP is a nucleocytoplasmic shuttling protein with a nuclear localization signal (NLS), whereas THOC7 does not contain a typical NLS motif. We show here that THOC7 (50–137, amino acid numbers) binds to the N-terminal portion (1–199) of FMIP directly. FMIP is detected mainly in the nucleus. In the absence of exogenous FMIP, THOC7 resides mainly in the cytoplasm, while in the presence of FMIP, THOC7 is transported into the nucleus with FMIP. Furthermore, THOC7 lacking the FMIP binding site does not co-localize with FMIP, indicating that THOC7/FMIP interaction is required for nuclear localization of THOC7. MINT-6799962, MINT-6799973, MINT-6800005: THOC7 (uniprotkb:Q6I9Y2) physically interacts (MI:0218) with THOC5 (uniprotkb:Q13769) by pull down (MI:0096) MINT-6800108: FMIP (uniprotkb:Q13769) and THOC7 (uniprotkb: Q6I9Y2) co-localize (MI:0403) by fluorescence microscopy (MI:0416) MINT-6800052: FMIP (uniprotkb:Q13769) physically interacts (MI:0218) with THOC1 (uniprotkb: Q96FV9) by anti tag coimmunoprecipitation (MI:0007) MINT-6800022: THOC7 (uniprotkb:Q6I9Y2) physically interacts (MI:0218) with FMIP (uniprotkb:Q6DFL5) by pull down (MI:0096) MINT-6799989: THOC7 (uniprotkb:Q6I9Y2) binds (MI:0407) to FMIP (uniprotkb:Q13769) by pull down (MI:0096) MINT-6800071, MINT-6800089: FMIP (uniprotkb:Q13769) physically interacts (MI:0218) with THOC7 (uniprotkb:Q6I9Y2) and THOC1 (uniprotkb:Q96FV9) by anti tag coimmunoprecipitation (MI:0007)</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2008.11.024</identifier><identifier>PMID: 19059247</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Amino Acid Motifs - genetics ; Animals ; Cell Nucleus - metabolism ; FMIP/THOC5/fSAP79 ; Humans ; Mice ; mRNA processing complex ; Mutation ; Nuclear Localization Signals - genetics ; Nuclear Localization Signals - metabolism ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Nucleocytoplasmic shuttling protein ; Protein Interaction Mapping ; RNA Precursors - metabolism ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; THOC7/fSAP24 ; Xenopus ; Xenopus Proteins - genetics ; Xenopus Proteins - metabolism</subject><ispartof>FEBS letters, 2009-01, Vol.583 (1), p.13-18</ispartof><rights>2008</rights><rights>FEBS Letters 583 (2009) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5064-3432c4986ff866f0e82e2c0558c66e25ff41fd507b80cc3fac1ba946d2856ee03</citedby><cites>FETCH-LOGICAL-c5064-3432c4986ff866f0e82e2c0558c66e25ff41fd507b80cc3fac1ba946d2856ee03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579308009344$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19059247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El Bounkari, Omar</creatorcontrib><creatorcontrib>Guria, Anuja</creatorcontrib><creatorcontrib>Klebba-Faerber, Sabine</creatorcontrib><creatorcontrib>Claußen, Maike</creatorcontrib><creatorcontrib>Pieler, Tomas</creatorcontrib><creatorcontrib>Griffiths, John R.</creatorcontrib><creatorcontrib>Whetton, Anthony D.</creatorcontrib><creatorcontrib>Koch, Alexandra</creatorcontrib><creatorcontrib>Tamura, Teruko</creatorcontrib><title>Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP)</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>THOC7 and Fms-interacting protein (FMIP) are members of the THO complex that associate with the mRNA export apparatus. FMIP is a nucleocytoplasmic shuttling protein with a nuclear localization signal (NLS), whereas THOC7 does not contain a typical NLS motif. We show here that THOC7 (50–137, amino acid numbers) binds to the N-terminal portion (1–199) of FMIP directly. FMIP is detected mainly in the nucleus. In the absence of exogenous FMIP, THOC7 resides mainly in the cytoplasm, while in the presence of FMIP, THOC7 is transported into the nucleus with FMIP. Furthermore, THOC7 lacking the FMIP binding site does not co-localize with FMIP, indicating that THOC7/FMIP interaction is required for nuclear localization of THOC7. MINT-6799962, MINT-6799973, MINT-6800005: THOC7 (uniprotkb:Q6I9Y2) physically interacts (MI:0218) with THOC5 (uniprotkb:Q13769) by pull down (MI:0096) MINT-6800108: FMIP (uniprotkb:Q13769) and THOC7 (uniprotkb: Q6I9Y2) co-localize (MI:0403) by fluorescence microscopy (MI:0416) MINT-6800052: FMIP (uniprotkb:Q13769) physically interacts (MI:0218) with THOC1 (uniprotkb: Q96FV9) by anti tag coimmunoprecipitation (MI:0007) MINT-6800022: THOC7 (uniprotkb:Q6I9Y2) physically interacts (MI:0218) with FMIP (uniprotkb:Q6DFL5) by pull down (MI:0096) MINT-6799989: THOC7 (uniprotkb:Q6I9Y2) binds (MI:0407) to FMIP (uniprotkb:Q13769) by pull down (MI:0096) MINT-6800071, MINT-6800089: FMIP (uniprotkb:Q13769) physically interacts (MI:0218) with THOC7 (uniprotkb:Q6I9Y2) and THOC1 (uniprotkb:Q96FV9) by anti tag coimmunoprecipitation (MI:0007)</description><subject>Amino Acid Motifs - genetics</subject><subject>Animals</subject><subject>Cell Nucleus - metabolism</subject><subject>FMIP/THOC5/fSAP79</subject><subject>Humans</subject><subject>Mice</subject><subject>mRNA processing complex</subject><subject>Mutation</subject><subject>Nuclear Localization Signals - genetics</subject><subject>Nuclear Localization Signals - metabolism</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Nucleocytoplasmic shuttling protein</subject><subject>Protein Interaction Mapping</subject><subject>RNA Precursors - metabolism</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>THOC7/fSAP24</subject><subject>Xenopus</subject><subject>Xenopus Proteins - genetics</subject><subject>Xenopus Proteins - metabolism</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkt9uFCEUxonR2G31ETRcGb2YERiGgStTN123SW2N1mvCMgfLOn-2A2OzfRCfV8bZpN7VKwL8zvdx-A5CryjJKaHi_TZ3sAkNxJwRInNKc8L4E7Sgsiqyggv5FC0IoTwrK1UcoeMQtiTtJVXP0RFVpFSMVwv0-3K0DZgBN701jb830fcd7h2ON4B3A2Tt18tTbELorU933Y902EfwHb5eXy0rXMMOujrgcZfKfAy49gPYiH0XYTD2r9qdjzd41QYc90MffAf4p-9MgAfoH9m3q8_nX969QM-caQK8PKwn6Pvq7Hq5zi6uPp0vTy8yWxLBU58Fs1xJ4ZwUwhGQDJglZSmtEMBK5zh1dUmqjSTWFs5YujGKi5rJUgCQ4gS9mXWT_e0IIerWBwtNYzrox6CFqCpFFH8UZJRyWhQqgeUM2tRrGMDp3eBbM-w1JXpKTm_1ITk9Jacp1Sm5VPf6YDBuWqgfqg5RJWA9A3e-gf3_qerV2Uf2bRqDaQqIJEQVfPL6MEtB-tpfHgYdrIfOwhyernv_yGv_AJC6w-I</recordid><startdate>20090105</startdate><enddate>20090105</enddate><creator>El Bounkari, Omar</creator><creator>Guria, Anuja</creator><creator>Klebba-Faerber, Sabine</creator><creator>Claußen, Maike</creator><creator>Pieler, Tomas</creator><creator>Griffiths, John R.</creator><creator>Whetton, Anthony D.</creator><creator>Koch, Alexandra</creator><creator>Tamura, Teruko</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20090105</creationdate><title>Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP)</title><author>El Bounkari, Omar ; Guria, Anuja ; Klebba-Faerber, Sabine ; Claußen, Maike ; Pieler, Tomas ; Griffiths, John R. ; Whetton, Anthony D. ; Koch, Alexandra ; Tamura, Teruko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5064-3432c4986ff866f0e82e2c0558c66e25ff41fd507b80cc3fac1ba946d2856ee03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amino Acid Motifs - genetics</topic><topic>Animals</topic><topic>Cell Nucleus - metabolism</topic><topic>FMIP/THOC5/fSAP79</topic><topic>Humans</topic><topic>Mice</topic><topic>mRNA processing complex</topic><topic>Mutation</topic><topic>Nuclear Localization Signals - genetics</topic><topic>Nuclear Localization Signals - metabolism</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Nucleocytoplasmic shuttling protein</topic><topic>Protein Interaction Mapping</topic><topic>RNA Precursors - metabolism</topic><topic>RNA-Binding Proteins - genetics</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>THOC7/fSAP24</topic><topic>Xenopus</topic><topic>Xenopus Proteins - genetics</topic><topic>Xenopus Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Bounkari, Omar</creatorcontrib><creatorcontrib>Guria, Anuja</creatorcontrib><creatorcontrib>Klebba-Faerber, Sabine</creatorcontrib><creatorcontrib>Claußen, Maike</creatorcontrib><creatorcontrib>Pieler, Tomas</creatorcontrib><creatorcontrib>Griffiths, John R.</creatorcontrib><creatorcontrib>Whetton, Anthony D.</creatorcontrib><creatorcontrib>Koch, Alexandra</creatorcontrib><creatorcontrib>Tamura, Teruko</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Bounkari, Omar</au><au>Guria, Anuja</au><au>Klebba-Faerber, Sabine</au><au>Claußen, Maike</au><au>Pieler, Tomas</au><au>Griffiths, John R.</au><au>Whetton, Anthony D.</au><au>Koch, Alexandra</au><au>Tamura, Teruko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP)</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2009-01-05</date><risdate>2009</risdate><volume>583</volume><issue>1</issue><spage>13</spage><epage>18</epage><pages>13-18</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>THOC7 and Fms-interacting protein (FMIP) are members of the THO complex that associate with the mRNA export apparatus. FMIP is a nucleocytoplasmic shuttling protein with a nuclear localization signal (NLS), whereas THOC7 does not contain a typical NLS motif. We show here that THOC7 (50–137, amino acid numbers) binds to the N-terminal portion (1–199) of FMIP directly. FMIP is detected mainly in the nucleus. In the absence of exogenous FMIP, THOC7 resides mainly in the cytoplasm, while in the presence of FMIP, THOC7 is transported into the nucleus with FMIP. Furthermore, THOC7 lacking the FMIP binding site does not co-localize with FMIP, indicating that THOC7/FMIP interaction is required for nuclear localization of THOC7. MINT-6799962, MINT-6799973, MINT-6800005: THOC7 (uniprotkb:Q6I9Y2) physically interacts (MI:0218) with THOC5 (uniprotkb:Q13769) by pull down (MI:0096) MINT-6800108: FMIP (uniprotkb:Q13769) and THOC7 (uniprotkb: Q6I9Y2) co-localize (MI:0403) by fluorescence microscopy (MI:0416) MINT-6800052: FMIP (uniprotkb:Q13769) physically interacts (MI:0218) with THOC1 (uniprotkb: Q96FV9) by anti tag coimmunoprecipitation (MI:0007) MINT-6800022: THOC7 (uniprotkb:Q6I9Y2) physically interacts (MI:0218) with FMIP (uniprotkb:Q6DFL5) by pull down (MI:0096) MINT-6799989: THOC7 (uniprotkb:Q6I9Y2) binds (MI:0407) to FMIP (uniprotkb:Q13769) by pull down (MI:0096) MINT-6800071, MINT-6800089: FMIP (uniprotkb:Q13769) physically interacts (MI:0218) with THOC7 (uniprotkb:Q6I9Y2) and THOC1 (uniprotkb:Q96FV9) by anti tag coimmunoprecipitation (MI:0007)</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>19059247</pmid><doi>10.1016/j.febslet.2008.11.024</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Amino Acid Motifs - genetics
Animals
Cell Nucleus - metabolism
FMIP/THOC5/fSAP79
Humans
Mice
mRNA processing complex
Mutation
Nuclear Localization Signals - genetics
Nuclear Localization Signals - metabolism
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Nucleocytoplasmic shuttling protein
Protein Interaction Mapping
RNA Precursors - metabolism
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
THOC7/fSAP24
Xenopus
Xenopus Proteins - genetics
Xenopus Proteins - metabolism
title Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP)
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