Two New Biologically Active Cyclopentenones from Dasyscyphus sp. A47-98

Two new biological active cyclopentenones VM 4798-1a (1a) and VM 4798-1b (1b) were obtained as a 3:1 inseparable mixture from fermentations of Dasyscyphus sp. A47-98. The mixture of the two isomers showed cytotoxic and weak antibacterial and antifungal properties. VM 4898-1 (2-hydroxy-3, 4-dimethyl-...

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Bibliographic Details
Published in:Journal of antibiotics 2004/05/25, Vol.57(5), pp.311-315
Main Authors: MIERAU, VIKTOR, STERNER, OLOV, ANKE, TIMM
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Cell Survival - drug effects
Chromatography, High Pressure Liquid
Dasyscyphus
Drug Screening Assays, Antitumor
Fermentation
Fungi - drug effects
Fungi - metabolism
HeLa Cells
Humans
Lactones - isolation & purification
Lactones - pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Nucleic Acid Synthesis Inhibitors - pharmacology
Protein Synthesis Inhibitors
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
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Summary:Two new biological active cyclopentenones VM 4798-1a (1a) and VM 4798-1b (1b) were obtained as a 3:1 inseparable mixture from fermentations of Dasyscyphus sp. A47-98. The mixture of the two isomers showed cytotoxic and weak antibacterial and antifungal properties. VM 4898-1 (2-hydroxy-3, 4-dimethyl-2-cyclopenten-1-one, 4), produced by another Dasyscyphus sp. showed no significant biological activity. The structures were elucidated by NMR techniques.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.57.311