Forced Peptide Synthesis in Nanoscale Confinement under Elastomeric Stamps

Pressing a rubber stamp inked with carboxylic acids onto an amine‐terminated surface leads to the formation of amide bonds at room temperature (see scheme). Oligopeptides were created on the surface in this way from a monolayer. This rapid and uncatalyzed formation of amide bonds is attributed to th...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2004-08, Vol.43 (32), p.4190-4193
Main Authors: Sullivan, Terena P., van Poll, Maaike L., Dankers, Patricia Y. W., Huck, Wilhelm T. S.
Format: Article
Language:English
Subjects:
3T3 Cells
Amino Acids - chemistry
Animals
Cell Adhesion
contact printing
DNA - chemistry
Elastomers - chemistry
Fluorenes - chemistry
Formic Acid Esters - chemistry
Linear Models
Mice
nanotechnology
Nanotechnology - methods
Oligopeptides - chemistry
Peptide Nucleic Acids - chemical synthesis
Peptide Nucleic Acids - chemistry
peptides
Peptides - chemical synthesis
surface chemistry
Thermodynamics
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Summary:Pressing a rubber stamp inked with carboxylic acids onto an amine‐terminated surface leads to the formation of amide bonds at room temperature (see scheme). Oligopeptides were created on the surface in this way from a monolayer. This rapid and uncatalyzed formation of amide bonds is attributed to the nanoscale confinement of the molecules between the stamp and the preorganized monolayer substrate. PDMS=poly(dimethylsiloxane).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200460271