Hereditary equine regional dermal asthenia ('hyperelastosis cutis') in 50 horses: clinical, histological, immunohistological and ultrastructural findings

Data on fifty horses with hereditary equine regional dermal asthenia (HERDA; ‘hyperelastosis cutis’) were collected on clinical, histopathological, ultrastructural and immunohistological findings. All horses were Quarter horses or of Quarter horse ancestry. Pedigree evaluation strongly supported an...

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Published in:Veterinary dermatology 2004-08, Vol.15 (4), p.207-217
Main Authors: WHITE, STEPHEN D., AFFOLTER, VERENA K., BANNASCH, DANIKA L., SCHULTHEISS, PATRICIA C., HAMAR, DWAYNE W., CHAPMAN, PHILLIP L., NAYDAN, DIANE, SPIER, SHARON J., ROSYCHUK, ROD A. W., REES, CHRISTINE, VENEKLASEN, GREGG O., MARTIN, ALONDRA, BEVIER, DIANE, JACKSON, HILARY A., BETTENAY, SONYA, MATOUSEK, JENNIFER, CAMPBELL, KAREN L., IHRKE, PETER J.
Format: Article
Language:English
Subjects:
Animals
Cohort Studies
collagen
Diagnosis, Differential
Ehlers-Danlos Syndrome - diagnosis
Ehlers-Danlos Syndrome - veterinary
Female
Genetic Predisposition to Disease
HERDA
hereditary equine regional dermal asthenia
Horse Diseases - diagnosis
Horse Diseases - genetics
Horse Diseases - pathology
Horses
hyperelastosis cutis
Immunohistochemistry - veterinary
Male
Pedigree
Prospective Studies
Retrospective Studies
skin
Skin - pathology
Skin - ultrastructure
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Summary:Data on fifty horses with hereditary equine regional dermal asthenia (HERDA; ‘hyperelastosis cutis’) were collected on clinical, histopathological, ultrastructural and immunohistological findings. All horses were Quarter horses or of Quarter horse ancestry. Pedigree evaluation strongly supported an autosomal recessive mode of inheritance. The most common lesions were seromas/haematomas, open wounds, sloughing skin, and loose, easily tented skin that did not return to its initial position. Definitive diagnosis could not be made via histopathology, although the presence of tightly grouped thin and shortened collagen fibres arranged in clusters in the deep dermis was suggestive of the disease. Trichrome, acid orcein‐Giemsa and immunohistochemical stains for collagens I and III showed no consistent abnormalities compared to control horses; an increase in elastic fibres was not a consistent finding. Electron microscopy showed no abnormalities in the periodicity of the collagen bundles; neither orientation nor variation of cross‐section diameter of the collagen fibrils differentiated control from affected horses. The diagnosis of HERDA relies on clinical presentation, but may be supported by suggestive (although not pathognomonic) histopathological lesions.
ISSN:0959-4493
1365-3164
DOI:10.1111/j.1365-3164.2004.00402.x