Cerebellar medulloblastoma in the elderly

Abstract Although medulloblastoma is the most common central nervous system malignancy in children, cases are much less common in adults. Moreover, this tumor is exceedingly rare in patients older than 65 years. Analysis of previous case reports reveals that medulloblastoma in the elderly is more co...

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Bibliographic Details
Published in:Annals of diagnostic pathology 2009-02, Vol.13 (1), p.55-59
Main Authors: Huppmann, Alison R., MD, Orenstein, Jan M., MD, PhD, Jones, Robert V., MD
Format: Article
Language:English
Subjects:
Aged
Brain neoplasms
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - surgery
Cerebellum
Elderly
Female
Humans
Immunohistochemistry
Male
Medulloblastoma
Medulloblastoma - pathology
Medulloblastoma - surgery
Pathology
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Summary:Abstract Although medulloblastoma is the most common central nervous system malignancy in children, cases are much less common in adults. Moreover, this tumor is exceedingly rare in patients older than 65 years. Analysis of previous case reports reveals that medulloblastoma in the elderly is more commonly seen in males in a lateral location; histologically, medulloblastomas in aged individuals usually belong to the classic subtype. During intraoperative consultation, the pathologist should consider medulloblastoma in the differential diagnosis of a cerebellar mass in the elderly because cytologic features may overlap with metastatic small cell carcinoma or lymphoma. We present a case of medulloblastoma in a 66-year-old man and review the literature on the subject.
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2007.06.002