5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations

Sustainable observations suggest that suicidal behaviour by itself may have biological correlates, among which those related to the serotonergic synapse hold the key position. Based on the association of suicide and serotonergic dysfunction, it was proposed that genetic mechanisms affecting suicidal...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2004-08, Vol.254 (4), p.224-227
Main Authors: Stefulj, Jasminka, Büttner, Andreas, Kubat, Milovan, Zill, Peter, Balija, Melita, Eisenmenger, Wolfgang, Bondy, Brigitta, Jernej, Branimir
Format: Article
Language:English
Subjects:
Adult
Cysteine - genetics
Demography
European Continental Ancestry Group - ethnology
European Continental Ancestry Group - genetics
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Receptor, Serotonin, 5-HT2C - genetics
Reverse Transcriptase Polymerase Chain Reaction - methods
RNA, Messenger - biosynthesis
Serine - genetics
Suicide - ethnology
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Summary:Sustainable observations suggest that suicidal behaviour by itself may have biological correlates, among which those related to the serotonergic synapse hold the key position. Based on the association of suicide and serotonergic dysfunction, it was proposed that genetic mechanisms affecting suicidal behaviour could be related to the alterations of the genes encoding the elements of 5HT synapse. The present study tested the association of the polymorphism in the serotonin 2C (5HT-2C) receptor coding region (Cys23Ser) with suicide commitment. Study was based on two independent samples, one of German (284 suicide victims versus 297 controls) and other of Slavic/Croatian (118 suicide victims versus 275 controls) ethnicity. No significant differences in allele or genotype frequencies between victims and controls were demonstrated. Results did not provide supporting evidence for the potential involvement of the investigated variants of 5HT-2C receptor in the susceptibility to suicide.
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-004-0482-5