Catalyzed Dehydrogenative Coupling of Primary Alcohols with Water, Methanol, or Amines

A working partnership: Metal–ligand cooperativity is responsible for the high activity of the rhodium amido complex 1 in the dehydrogenative coupling of primary alcohols with water, methanol, or amines, including ammonia (see scheme), to give carboxylic acids, methyl carboxylates, or amides, respect...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (3), p.559-563
Main Authors: Zweifel, Theo, Naubron, Jean-Valère, Grützmacher, Hansjörg
Format: Article
Language:English
Subjects:
alcohols
amines
density functional calculations
homogeneous catalysis
rhodium
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Summary:A working partnership: Metal–ligand cooperativity is responsible for the high activity of the rhodium amido complex 1 in the dehydrogenative coupling of primary alcohols with water, methanol, or amines, including ammonia (see scheme), to give carboxylic acids, methyl carboxylates, or amides, respectively. The catalysis proceeds under mild reaction conditions in the presence of a recyclable hydrogen acceptor A. The multistep mechanism was elucidated by computational methods.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200804757