Medication effects on the rate of orthodontic tooth movement: A systematic literature review

Introduction Recently, several reviews have been published on the effects of medications on bone physiology and the clinical side effects in orthodontics. However, the effects of medications on the rate of orthodontic tooth movement have not been evaluated. Methods A systematic literature review on...

Full description

Saved in:
Bibliographic Details
Published in:American journal of orthodontics and dentofacial orthopedics 2009, Vol.135 (1), p.16-26
Main Authors: Bartzela, Theodosia, Türp, Jens C, Motschall, Edith, Maltha, Jaap C
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Anti-Inflammatory Agents - pharmacology
Biological and medical sciences
Bone Density Conservation Agents - pharmacology
Calcium - pharmacology
Dentistry
Dietary Supplements
Drug Therapy
Hormones - pharmacology
Humans
Medical sciences
Otorhinolaryngology. Stomatology
Pharmacology
Tooth - drug effects
Tooth Movement Techniques
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Recently, several reviews have been published on the effects of medications on bone physiology and the clinical side effects in orthodontics. However, the effects of medications on the rate of orthodontic tooth movement have not been evaluated. Methods A systematic literature review on the effects of medications and dietary supplements on the rate of experimental tooth movement was performed by using PubMed (1953-Oct 2007), Web of Science, and Biosis, complemented by a hand search. Results Forty-nine articles were included in the review, but their interpretation was hindered by the variability in experimental design, magnitude of force applied during tooth movement, and medication regimens. Therapeutic administration of eicosanoids resulted in increased tooth movement, whereas their blocking led to a decrease. Nonsteroidal anti-inflammatory drugs (NSAIDs) decreased tooth movement, but non-NSAID analgesics, such as paracetamol (acetaminophen), had no effect. Corticosteroid hormones, parathyroid hormone, and thyroxin have all been shown to increase tooth movement. Estrogens probably reduce tooth movement, although no direct evidence is available. Vitamin D3 stimulates tooth movement, and dietary calcium seemed to reduce it. Bisphosphonates had a strong inhibitory effect. Conclusions Medications might have an important influence on the rate of tooth movement, and information on their consumption is essential to adequately discuss treatment planning with patients.
ISSN:0889-5406
1097-6752
DOI:10.1016/j.ajodo.2008.08.016