Boron biodistribution in Beagles after intravenous infusion of 4-dihydroxyborylphenylalanine–fructose complex

• Published in: Applied radiation and isotopes 2004-11, Vol.61 (5), p.975-979
• Main Authors: Kulvik, M.E, Vähätalo, J.K, Benczik, J, Snellman, M, Laakso, J, Hermans, R, Järviluoma, E, Rasilainen, M, Färkkilä, M, Kallio, M.E
• Format: Article
• Language: English
• Subjects: Animal study; Animals; BNCT; Boron - blood; Boron - pharmacokinetics; Boron biodistribution; Boron Compounds - administration & dosage; Boron Compounds - blood; Boron Compounds - pharmacokinetics; Boron Neutron Capture Therapy; BPA; Brain - metabolism; Dog; Dogs; Fructose - administration & dosage; Fructose - analogs & derivatives; Fructose - blood; Fructose - pharmacokinetics; Infusions, Intravenous; Tissue Distribution
• ISSN: 0969-8043; 1872-9800
• DOI: 10.1016/j.apradiso.2004.05.022

Boron biodistribution after intravenous infusion of 4-dihydroxyborylphenylalanine-fructose (BPA–F) complex was investigated in six dogs. Blood samples were evaluated during and following doses of 205 and 250 mg/kgbw BPA in a 30 min infusion, and 500 mg/kgbw in a 1 h infusion. Samples from whole blood, urine, brain and other organs were analysed for boron content after varying times following the onset of infusion. The whole blood boron concentrations declined from 27 to 8.4 ppm over the period of 39–165 min after the onset of infusion and the levels increased from 1.9 to 12 ppm in the grey matter of the brain over the same period. The boron concentrations in whole blood decreased steadily, whereas the boron values in brain tissue rose steadily with time. It was concluded that whole blood boron concentrations do not seem to reflect accurately the boron concentration in brain tissue at respective time points.