Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors

Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether polarity loss might causally contribute to cancer has remained unclear. In Drosophila, mutations in the "neoplastic tumor suppressor genes" (nTSGs) scribble, discs-large, and lethal giant larvae disru...

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Bibliographic Details
Published in:Genes & development 2004-08, Vol.18 (16), p.1909-1925
Main Author: Bilder, David
Format: Article
Language:English
Subjects:
Animals
Cell Division - genetics
Cell Polarity - genetics
Drosophila
Drosophila - cytology
Drosophila - genetics
Genes, Tumor Suppressor
Mammalia
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Summary:Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether polarity loss might causally contribute to cancer has remained unclear. In Drosophila, mutations in the "neoplastic tumor suppressor genes" (nTSGs) scribble, discs-large, and lethal giant larvae disrupt polarity of epithelia and neuroblasts, and simultaneously induce extensive overproliferation of these cells, which exhibit malignant-like characteristics. Herein I review what is known about the role of the fly nTSGs in controlling cell polarity and cell proliferation. Incorporating data from mammalian studies, I consider how polarity and proliferation can be coupled, and how disruption of polarity could promote cancer.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1211604