Immunotherapy in head and neck cancer: current practice and future possibilities

The survival of patients with head and neck squamous cell carcinoma has changed little over the last 30 years. However, with recent advances in the fields of cellular and molecular immunology, there is renewed optimism with regards to the development of novel methods of early diagnosis, prognosis es...

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Bibliographic Details
Published in:Journal of laryngology and otology 2009-01, Vol.123 (1), p.19-28
Main Authors: Agada, F O, Alhamarneh, O, Stafford, N D, Greenman, J
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - therapeutic use
Antigen presentation
Biological and medical sciences
Breast cancer
Cancer therapies
Cancer Vaccines - therapeutic use
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - therapy
Clinical Trials as Topic
Combined Modality Therapy
Cytokines
Cytokines - immunology
Cytotoxicity
Dendritic cells
Dendritic Cells - immunology
Epidermal growth factor
Head & neck cancer
Head and Neck Neoplasms
Head and Neck Neoplasms - immunology
Head and Neck Neoplasms - therapy
Humans
Immune system
Immunology
Immunotherapy
Immunotherapy - methods
Lymphocytes
Lymphocytes - immunology
Medical sciences
Melanoma
Monoclonal antibodies
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Prostate
Squamous Carcinoma
Tumor necrosis factor-TNF
Tumors
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Summary:The survival of patients with head and neck squamous cell carcinoma has changed little over the last 30 years. However, with recent advances in the fields of cellular and molecular immunology, there is renewed optimism with regards to the development of novel methods of early diagnosis, prognosis estimation and treatment improvement for patients with head and neck squamous cell carcinoma. Here, we present a critical review of the recent advances in tumour immunology, and of the current efforts to apply new immunotherapeutic techniques in the treatment of head and neck squamous cell carcinoma.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215108003356