The Enantioselective Synthesis of α-Amino Acids by Phase-Transfer Catalysis with Achiral Schiff Base Esters

The development and application of chiral phase-transfer catalysis (PTC) for the enantioselective synthesis of optically active α-amino acid derivatives using achiral Schiff base esters developed in the author's laboratory and by others is reviewed. Phase-transfer catalysts derived from the Cin...

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Bibliographic Details
Published in:Accounts of chemical research 2004-08, Vol.37 (8), p.506-517
Main Author: O'Donnell, Martin J
Format: Article
Language:English
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Summary:The development and application of chiral phase-transfer catalysis (PTC) for the enantioselective synthesis of optically active α-amino acid derivatives using achiral Schiff base esters developed in the author's laboratory and by others is reviewed. Phase-transfer catalysts derived from the Cinchona alkaloids have been exploited as inexpensive and attractive organocatalysts in the chiral PTC process. The recent evolution and use of these and other catalytic systems is described.
ISSN:0001-4842
1520-4898
DOI:10.1021/ar0300625