Associations of polymorphisms in the Pit-1 gene with growth and carcass traits in Angus beef cattle

The Pit-1 gene was studied as a candidate for genetic markers of growth and carcass traits. Angus beef cattle that were divergently selected for high- or low-blood serum IGF-I concentration were used in this study. The single-strand conformation polymorphism method was used to identify polymorphism...

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Bibliographic Details
Published in:Journal of animal science 2004-08, Vol.82 (8), p.2229-2233
Main Authors: Zhao, Q, Davis, M.E, Hines, H.C
Format: Article
Language:English
Subjects:
Angus
animal genetics
animal growth
Animal productions
Animals
beef cattle
beef quality
biochemical polymorphism
Biological and medical sciences
Body Composition - genetics
Bos
carcass characteristics
Cattle - genetics
Cattle - growth & development
DNA-Binding Proteins - genetics
Exons
Female
Food industries
Fundamental and applied biological sciences. Psychology
Genetic Linkage
Genetic Markers
genetic variation
genotype
growth traits
insulin-like growth factor I
Insulin-Like Growth Factor I - analysis
Insulin-Like Growth Factor I - genetics
Introns
Linear Models
Male
Meat and meat product industries
molecular sequence data
Pit-1 gene
Polymorphism, Single-Stranded Conformational
Quantitative Trait, Heritable
Random Allocation
Selection, Genetic
sequence analysis
single-stranded conformational polymorphism
Terrestrial animal productions
Transcription Factor Pit-1
Transcription Factors - genetics
Vertebrates
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Summary:The Pit-1 gene was studied as a candidate for genetic markers of growth and carcass traits. Angus beef cattle that were divergently selected for high- or low-blood serum IGF-I concentration were used in this study. The single-strand conformation polymorphism method was used to identify polymorphism in the Pit-1 gene including regions from intron 2 to exon 6. Two polymorphisms, Pit1I3H (HinfI) and Pit1I3NL (NlaIII), were detected in intron 3 of the Pit-1 gene. One polymorphism, Pit1I4N (BstNI), was found in intron 4, and a single nucleotide polymorphism, Pit1I5, was found in intron 5. The previously reported polymorphism in exon 6, Pit1E6H (HinfI), was also studied in 416 Angus beef cattle. Associations of the polymorphisms with growth traits, carcass traits, and IGF-I concentration were analyzed using a general linear model procedure. No significant associations were observed between these polymorphisms and growth and carcass traits.
ISSN:0021-8812
1525-3163
DOI:10.2527/2004.8282229x