Nanofabricated upconversion nanoparticles for photodynamic therapy

We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We sho...

Full description

Saved in:
Bibliographic Details
Published in:Optics express 2009-01, Vol.17 (1), p.80-86
Main Authors: Ungun, Baris, Prud'homme, Robert K, Budijon, Stephanie J, Shan, Jingning, Lim, Shuang F, Ju, Yiguang, Austin, Robert
Format: Article
Language:English
Subjects:
Biocompatible Materials
Humans
Light
Metals, Rare Earth - radiation effects
Mononuclear Phagocyte System - physiology
Mononuclear Phagocyte System - radiation effects
Nanoparticles
Nanotechnology - methods
Particle Size
Photochemotherapy - instrumentation
Photochemotherapy - methods
Photons
Photosensitizing Agents
Polyethylene Glycols
Porphyrins
Singlet Oxygen - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.
ISSN:1094-4087
1094-4087
DOI:10.1364/oe.17.000080