Hysterectomy and bilateral oophorectomy for severe premenstrual syndrome

• Published in: Human reproduction (Oxford) 2004-09, Vol.19 (9), p.2152-2155
• Main Authors: Cronje, W.H., Vashisht, A., Studd, J.W.W.
• Format: Article
• Language: English
• Subjects: Administration, Cutaneous; Adult; Biological and medical sciences; Drug Implants; Embryology: invertebrates and vertebrates. Teratology; Estradiol - administration & dosage; Estradiol - therapeutic use; Female; Fundamental and applied biological sciences. Psychology; HRT; Humans; Hysterectomy; Interviews as Topic; Middle Aged; oophorectomy; Ovariectomy; Patient Satisfaction; Postoperative Care; premenstrual syndrome; Premenstrual Syndrome - physiopathology; Premenstrual Syndrome - surgery; Severity of Illness Index; Surveys and Questionnaires; Testosterone - administration & dosage; Testosterone - therapeutic use; Treatment Outcome
• ISSN: 0268-1161; 1460-2350; 1460-2350
• DOI: 10.1093/humrep/deh354

BACKGROUND: Premenstrual syndrome (PMS) is a chronic, poorly understood psycho-endocrine disorder severely affecting 5%; of women. Hormonal therapy which suppresses ovulation is the mainstay of medical treatment, but these interventions are rarely permanent. We evaluated the effectiveness and patient satisfaction with total abdominal hysterectomy/bilateral salpingo-oophorectomy (TAH/BSO) in PMS sufferers, and assessed the post-operative HRT continuation. METHODS: All women undergoing TAH/BSO for severe PMS between January 1994 and April 2000 were interviewed and responses recorded by structured questionnaire. RESULTS: Forty-seven women were interviewed. Median age was 42 years (interquartile range 39.8–46.6) at the time of surgery. They had suffered with PMS for a mean of 9.68 years (SD 6.8) and received treatment for a mean of 3.57 years (SD 2.0) prior to referral to a gynaecologist. Fifty-two percent were treated with estradiol patches and 48% with estradiol implants prior to TAH/BSO. Ninety-six percent of women were ‘satisfied’ or ‘very satisfied’ with TAH/BSO, and 93.6% declared complete resolution of their cyclical symptoms; 93.6% were continuing with HRT usually by implants of estradiol and testosterone for a mean duration of 3.8 years (SD 1.86) post-operatively. CONCLUSION: Despite few reports of TAH/BSO as a treatment for severe PMS, we have found surgery, coupled with appropriate HRT, to be an extremely effective and well-accepted permanent cure for PMS.