Elevated Concentrations of Liver Enzymes and Ferritin Identify a New Phenotype of Insulin Resistance: Effect of Weight Loss After Gastric Banding

Background Several studies have associated elevated liver enzymes (LFTs), obesity, and type 2 diabetes (T2DM), and a link has been established between insulin resistance (IR) and elevated ferritin concentrations. We examined the relationship between LFTs, ferritin, and IR in morbid obese subjects an...

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Bibliographic Details
Published in:Obesity surgery 2009, Vol.19 (1), p.80-86
Main Authors: Gastaldelli, Amalia, Perego, Lucia, Paganelli, Michele, Sesti, Giorgio, Hribal, Marta, Chavez, Alberto O., DeFronzo, Ralph A., Pontiroli, Antonio, Folli, Franco
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Clinical outcomes
Cohort Studies
Diabetes
Enzymes
Female
Ferritins - blood
Gastrointestinal surgery
Gastroplasty
Genotype & phenotype
Humans
Insulin resistance
Insulin Resistance - physiology
Laparoscopy
Liver
Liver Function Tests
Male
Medicine
Medicine & Public Health
Obesity
Obesity, Morbid - metabolism
Obesity, Morbid - surgery
Research Article
Retrospective Studies
Surgery
Transaminases - blood
Weight control
Weight Loss - physiology
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Summary:Background Several studies have associated elevated liver enzymes (LFTs), obesity, and type 2 diabetes (T2DM), and a link has been established between insulin resistance (IR) and elevated ferritin concentrations. We examined the relationship between LFTs, ferritin, and IR in morbid obese subjects and the effect of weight loss after bariatric surgery. Methods We measured liver enzymes, ferritin, insulin resistance, and glucose tolerance (by OGTT) in 159 morbid obese subjects (BMI = 44.4 ± 0.4 kg/m 2 ) at baseline, 6 months and 1 year after laparoscopic-adjustable-gastric banding (LAGB). Subjects were divided in two groups: increased LFTs (ALT > 30; AST/ALT 
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-008-9690-9