Central nervous system abnormalities in vaginismus

• Published in: Clinical neurophysiology 2009-01, Vol.120 (1), p.117-122
• Main Authors: Frasson, Emma, Graziottin, Alessandra, Priori, Alberto, Dall’Ora, Elisa, Didonè, Giuseppe, Garbin, Emilio Luigi, Vicentini, Silvana, Bertolasi, Laura
• Format: Article
• Language: English
• Subjects: Adult; Anal Canal - innervation; Attention deficit disorders. Hyperactivity; Biological and medical sciences; Bulbocavernosus reflex; Case-Control Studies; Child clinical studies; Electric Stimulation; Electrodiagnosis. Electric activity recording; Electromyography; EMG; Evoked Potentials, Somatosensory - physiology; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Lifelong vaginismus; Medical sciences; Muscle, Skeletal - physiopathology; Nervous system; Nervous System Malformations - etiology; Neural Inhibition - physiology; Neurology; Pelvic Floor - innervation; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Pudendal SEPs; Reflex - physiology; Time Factors; Vaginismus - complications; Vaginismus - pathology; Vulvar vestibulitis syndrome
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2008.10.156

Abstract Objective To investigate possible altered CNS excitability in vaginismus. Methods In 10 patients with primary idiopathic lifelong vaginismus, 10 with vulvar vestibulitis syndrome accompanied by vaginismus and healthy controls we recorded EMG activity from the levator ani (LA) and external anal sphincter (EAS) muscles and tested bulbocavernosus reflex (BCR). Pudendal-nerve somatosensory evoked potentials (SEPs) were tested after a single stimulus. Pudendal-nerve SEP recovery functions were assessed using a paired conditioning-test paradigm at interstimulus intervals (ISIs) of 5, 20 and 40 ms. Results EMG in patients showed muscular hyperactivity at rest and reduced inhibition during straining. The BCR polysynaptic R2 had larger amplitude ( p < 0.01) and longer duration ( p < 0.01) in patients from both groups than in controls. In controls, paired-pulse SEPs were suppressed at the 5 ms ISI for N35–P40 ( p < 0.05) and P40–N50 ms ( p < 0.001) and facilitated at the 20 ms ISI for N35–P40 ( p < 0.05) and P40–N50 ( p < 0.05). No significant differences were found in the paired-pulse N35–P40 in patients and controls but the cortical P40–N50 at 20 ISI was facilitated in patients ( p < 0.05). Conclusions EMG activity is enhanced and the cortical SEP recovery cycle and BCR are hyperexcitable in vaginismus. Significance The neurophysiological abnormalities in patients with vaginismus indicate concomitant CNS changes in this disorder.