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Effects of Copaifera langsdorffii Desf. on Ischemia-Reperfusion of Randomized Skin Flaps in Rats
Background Copaíba oil is an oleoresin obtained from the Copaiffera langsdorffii genus (Leguminoseae). It is widely used in folk medicine as an antiinflammatory, healing, and antiseptic agent. Comparative pharmacologic studies between different species of copaíba oils are scarce. Methods The protect...
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Published in: | Aesthetic plastic surgery 2009, Vol.33 (1), p.104-109 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Copaíba oil is an oleoresin obtained from the
Copaiffera
langsdorffii
genus (Leguminoseae). It is widely used in folk medicine as an antiinflammatory, healing, and antiseptic agent. Comparative pharmacologic studies between different species of copaíba oils are scarce.
Methods
The protective effect of
Copaiffera langsdorffii
was evaluated on an experimental model of random skin flaps on rat dorsums.
Results
Seventy-two Wistar rats (average weight = 216.8 g) were divided randomly into four equal groups (saline control, vehicle control, GT200—Test 1, and GT400—Test 2). A caudally based rectangular flap, 2.5–8.0 cm in size, was elevated on the back of the rat using McFarlane’s method. The flap was sutured back into its original place.
Copaifera
and control drugs (saline and Tween 80) were administered by gavage 24, 12, and 2 h prior to the beginning of the experiment followed by daily doses for the next 7 days. To observe the effects of
Copaifera
, laboratory analyses included plasma and tissue levels of tiobarbituric acid-reactive substances (TBARS) and reduced glutathione (GSH) and tissue levels of myeloperoxidase (MPO).
Conclusion
The oil-resin of copaíba presents discrete antilipoperoxidation action, intense antioxidant action, and antiinflammatory activity during the ischemia and reperfusion of randomized cutaneous flaps. The effects of ischemia-reperfusion are complex and substances capable of increasing the tolerance of tissue to those effects by reducing the production or neutralizing the action of free radicals are needed. |
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ISSN: | 0364-216X 1432-5241 |
DOI: | 10.1007/s00266-008-9263-2 |