IL-10 gene polymorphisms in infectious disease and SIDS

Interleukin-10 (IL-10) is a regulatory cytokine, and its principal role in vivo is to limit inflammatory response. IL-10 has been shown to influence both the susceptibility and course of various diseases, and the different polymorphisms in the IL-10 gene promoter have been associated with disease pr...

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Bibliographic Details
Published in:FEMS Immunology and Medical Microbiology 2004-09, Vol.42 (1), p.48-52
Main Author: Opdal, Siri Hauge
Format: Article
Language:English
Subjects:
Gene polymorphism
Genetic Predisposition to Disease
Haplotypes
Humans
Immune system
Infant
Infection
Infection - genetics
Infectious diseases
Inflammation
Inflammatory response
Interleukin 10
Interleukin-10 - genetics
Polymorphism, Genetic
SIDS
Sudden Infant Death - genetics
Sudden infant death syndrome
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Summary:Interleukin-10 (IL-10) is a regulatory cytokine, and its principal role in vivo is to limit inflammatory response. IL-10 has been shown to influence both the susceptibility and course of various diseases, and the different polymorphisms in the IL-10 gene promoter have been associated with disease prevalence and severity. The genes involved in the immune system are also assumed to be of importance with regard to sudden infant death syndrome (SIDS), and specific haplotypes in the IL-10 gene promoter have been reported associated both with SIDS and sudden unexpected death due to infection.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1016/j.femsim.2004.06.006