Phytoestrogen treatment induces testis alterations in dogs. Potential use in population control

Dog overpopulation is considered a human health risk; they are the terrestrial vector of rabies and reservoirs for other human diseases. Surgical neutering and intratesticular injections have been used in male dogs. Physiological and morphological alterations in reproductive organs can be induced by...

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Bibliographic Details
Published in:Veterinary research communications 2009, Vol.33 (1), p.87-95
Main Authors: Perez-Rivero, Juan-Jose, Martinez-Maya, Jose-Juan, Perez-Martinez, Mario, Aguilar-Setien, Alvaro, Garcia-Suarez, Maria-Dolores, Serrano, Hector
Format: Article
Language:English
Subjects:
animal reproduction
Animals
antifertility effect
Biomedical and Life Sciences
contraception
Contraceptive Agents, Male - administration & dosage
Contraceptive Agents, Male - pharmacology
contraceptives
coumestrol
Coumestrol - administration & dosage
Coumestrol - pharmacology
Dogs
drug evaluation
drug therapy
histology
hormonal regulation
Life Sciences
Male
males
oral administration
oral contraceptives
Original Article
physiological regulation
Phytoestrogens - administration & dosage
Phytoestrogens - pharmacology
Sperm Count - veterinary
spermatogenesis
spermatozoa
testes
Testis - drug effects
veterinary drugs
Veterinary Medicine/Veterinary Science
Zoology
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Summary:Dog overpopulation is considered a human health risk; they are the terrestrial vector of rabies and reservoirs for other human diseases. Surgical neutering and intratesticular injections have been used in male dogs. Physiological and morphological alterations in reproductive organs can be induced by phytoestrogens. Our goal was to evaluate the effect of oral coumestrol on dog ejaculates and testis histology. Two groups of 5 healthy adult dogs were used. One coumestrolcontaining biscuit was given once a week for a 4 week period to the experimental group. Ejaculates were obtained and evaluated. After treatment, testis were obtained and processed for histology. Compared to controls, treated dogs have reduced tubules (462 ± 1.4 vs 336 ± 2 μ²), spermatogenic epithelium (49.1 ± 0.01 vs 13.3 ± 0.01 μ²), and lumen opening (891 ± 1.4 vs 530 ± 26.9 μ). Ejaculates from treated animals have increased numbers of abnormal spermatozoa and reduced sperm concentration.
ISSN:0165-7380
1573-7446
DOI:10.1007/s11259-008-9077-3